【摘要】 目的研究普拉克索联合苯海索对帕金森患者认知功能及生活质量的影响。方法选取2017年5月至2018年12月就诊的帕金森患者50例,按照数字随机法分为单药治疗组与联合治疗组,单药治疗组患者口服盐酸苯海索,联合治疗组患者在单药治疗组的基础上加用普拉克索,比较2组患者治疗后的疗效,采用简易智能精神状态检查量表(MMSE)及蒙特利尔认知评定量表(MOCA)进行认知功能的评价,采用美国国立卫生研究院卒中量表(NIHSS)对2组患者治疗前和治疗后的神经功能缺损评分进行统计比较,采用健康状况调查简表(SF-36)对2组患者治疗结束后3个月的生活质量进行评价统计,观察2组患者临床症状改善时间,检测2组患者治疗前后脑源性神经营养因子(BDNF)、胱抑素C(CysC)和人S100B蛋白(S-100B)水平,并对2组患者治疗后的不良反应情况进行组间比较。结果联合治疗组患者治疗后总有效率,MMSE与MOCA评分生活质量评分均显著高于单药治疗组(P<0.05);联合治疗组患者治疗后NIHSS评分明显低于单药治疗组(P<0.05);联合治疗组患者临床症状改善时间均短于单药治疗组(P<0.05);联合治疗组治疗后BDNF水平明显高于单药治疗组,CysC和S-100B水平明显低于单药治疗组(P<0.05);联合治疗组患者治疗后不良反应发生率显著低于单药治疗组(P<0.05)。结论普拉克索与苯海索联合治疗帕金森,能够有效改善患者的认知功能以及生活质量,同时减少不良反应的发生。更多还原

【Abstract】 Objective To investigate the effects of pramipexole combined with benzhexol on cognitive function and life quality of patients with Parkinson’s disease.Methods A total of 50 patients with Parkinson’s disease who were treated in our hospital from May 2017 to December 2018 were enrolled in the study,who were were divided into two groups according to the digital random method:single drug treatment group and combination treatment group.The patients in single drug treatment group were treated by benzhexol hydrochloride,however,the patientsin combination treatment group,on the basis of single drug treatment group,were treated by pramipexole.Thet herapeutic effects were assessed by Mini-mental State Examination(MMSE) and Montreal Cognitive Assessment(MOCA) scales.The National Institute of Health stroke scale(NIH) was used to assess cognitive function of patients.NIHSS was used to compare the scores of neurological impairment before and after treatment between the two groups.The life quality of patients was evaluated by SF-36.Moreover the improvement time of clinical symptoms was was observed,and Brain-derived neurotrophic factor(BDNF),cystatin C(CysC) and human S100 B protein(S-100 B) levels were observed and compared between the two groups.Results After treatment the total effective rate in combination treatment group was significantly higher than that in single drug treatment group(P<0.05),and the scores of MMSE and MOCA in combinstion treatment group were significantly higher than those in single drug treatment group(P<0.05).However the scores of NIHSS in combination treatment group were significantly lower than those in single drug treatment group(P<0.05),and the life quality scores in combination treatment group were significantly higher than those in single drug treatment group(P<0.05).In addition the improvement time of clinical symptoms in combination treatment group was significantly shorter than that in single drug treatment group(P<0.05).The levels of BDNF in combined treatment group were significantly higher than those in single drug treatment group,while,the levels of CysC and S-100 B in combination treatment group were significantly lower than those in single drug treatment group(P<0.05).The incidence rate of adverse reactions in combination treatment group was significantly lower than that in single drug treatment group(P<0.05).Conclusion The combination application of praxole and benzodiazepine in treatment of Parkinson’s disease can effectively improve the cognitive function and life quality of patients,and can reduce the occurrence of adverse reactions,therefor,which is worthy of clinica promotion.更多还原