【摘要】 目的研究负压吸引联合前列地尔及依帕司他治疗糖尿病足部溃疡(diabetic foot ulcers,DFU)的临床效果。方法选取DFU患者54例。根据随机数字表法分为对照组和观察组各27例。2组均采用常规治疗方案。对照组采用负压吸引联合前列地尔治疗;观察组采取负压吸引联合前列地尔及依帕司他治疗。比较2组患者治疗后创面缩小率、创面肉芽组织覆盖率,创面肉芽组织生长厚度、创面细菌清除率及创面愈合时间。结果 2组创面缩小率均呈明显升高趋势,观察组创面缩小率高于对照组,组间、时点间、组间·时点间交互作用差异有统计学意义(P<0.01)。观察组创面肉芽组织覆盖率、肉芽组织生长厚度、细菌清除率均明显高于对照组,差异有统计学意义(P<0.01)。观察组创面愈合时间短于对照组(P<0.01)。结论负压吸引联合前列地尔及依帕司他治疗DFU患者效果显著,缩短溃疡愈合时间。更多还原

【Abstract】 Objective To evaulate the clinical efficacy of vacuum sealing drainage combined with Alprostadil and Apalstat in the treatment of diabetic foot ulcers(DFU). Methods Fifty-four patients with DFU were admitted to our research. According to random number table method, 27 cases were divided into control group and observation group. Routine treatment was adopted to both groups. Among them, patients in the control group were treated with vacuum sealing drainage combined with Alprostadil; patients in the observation group were treated with vacuum sealing drainage combined with Alprostadil and Apalstat. The reduction rate of wound,the cover rate of granulation tissue,the thickness of granulation tissue,the clearance rate of bacteria and the healing time of the wound were compared between two groups after treatment. Results In both groups the reduction rates of wound were increased significantly, and in observation group it was higher than that in the control group. And all of the difference between two groups at all time point were statistically significant(P<0.01). The growth thickness, coverage rate and bacterial clearance rate of granulation tissue in the observation group were higher than those in the control group, and the difference was statistically significant(P<0.01). The wound healing time of the observation group was lower than that of the control group(P<0.01). Conclusion Vacuum sealing drainage combined with Alprostadil and Apalstat in the treatment of DFU patients has a significant effect and shortens the healing time of ulcers.更多还原