【摘要】 采用薄膜旋转蒸发-超声法制备了纳米柠檬酸铁脂质体（FAC-Lip）.探究了光照、温度、pH对FAC-Lip降解的影响,采用零级动力学和一级动力学模型判断降解模型,计算出半衰期(t_1/2)和降解速率常数（k）;采用透析法测定了FAC-Lip和游离柠檬酸铁（Free-FAC）在模拟胃液中的稳定性和血浆中的释放情况.结果表明:FAC-Lip的降解符合一级动力学模型,光照、高温、pH过低或过高都会加速FAC-Lip的降解;在模拟胃液中FAC-Lip具有缓释性,且比Free-FAC稳定性好;在血浆中FAC-Lip也具有缓释性,降解属于双相动力学模型.更多还原

【Abstract】 Ferric citrate liposome（FAC-Lip） was prepared using a rotary-evaporated film-ultrasonication method.The effects of light,temperature,and pH on the degradation of FAC-Lip were explored.Zero-and first-order kinetic models were used to determine the degradation model,both half-life(t_1/2) and degradation rate constant（k） were calculated.The stability of FAC-Lip and free ferric citrate（Free-FAC） in simulated gastric fluid and plasma were determined by dialysis method.The results showed that the degradation of FAC-Lip conformed to the first-order kinetic model,and the degradation of FAC-Lip would be accelerated when it was exposed to light,high temperature,low or high pH,respectively.FAC-Lip in simulated gastric juice was sustained release and had better stability than Free-FAC.FAC-Lip was also sustained release in plasma and belong to a biphasic kinetic model.更多还原