【摘要】 目的探讨血栓弹力图(TEG)对心肺复苏成功患者术后凝血功能的评估价值。方法将2017年3月—2018年6月于我院进行治疗的23例心肺复苏患者作为观察组,另选取于我院进行健康体检的23例设为对照组。比较2组心肺复苏后48 h常规凝血和TEG指标水平,并进行相关性分析。结果观察组活化部分凝血活酶时间(APTT)、血小板(PLT)水平低于对照组,纤维蛋白原(Fib)水平高于对照组(P<0. 05)。观察组凝血反应时间(R)短于对照组,凝血形成速率(Angle)水平低于对照组,凝血形成时间(K)长于对照组,凝血最终强度(MA)水平高于对照组(P<0. 05)。R与凝血酶原时间(PT)、APTT呈正相关(r=0.283、0.452,P<0. 05、0.01),K与Fib、PLT呈负相关(r=-0.254、-0.354,P=0. 041、0.046),Angle与Fib、PLT呈正相关(r=0.267、5.362,P=0. 027、0.002),MA与Fib、PLT呈正相关(r=0.536、0.755,P<0. 001)。结论对心肺复苏成功患者术后48 h采用TEG检测可为患者对抗PLT药物的早期用药提高可靠依据。更多还原

【Abstract】 Objective To investigate value of thrombelastogram( TEG) in evaluation of postoperative coagulation function in patients with successful cardiopulmonary resuscitation. Methods A total of 23 patients with cardiopulmonary resuscitation during March 2017 and June 2018 were enrolled as observation group,while other 23 patients taking physical examinations at the same period were selected as control group. Levels of routine coagulation and TEG indexes were compared at 48 h after cardiopulmonary resuscitation were compared,and correlations were also analyzed in two groups. Results In observation group,levels of activated partial thromboplastin time( APTT) and platelets( PLT) were significantly lower,while fibrinogen( Fib) level was significantly higher than those in control group( P<0. 05). In observation group,values of response time( R) of coagulation and formation speed of coagulation( Angle) were significantly lower,while values of formation time of coagulation( K) and the final intension of coagulation( Ma) were significantly higher than those in control group( P<0. 05). R was positively correlated with prothrombin time( PT) and APTT( r = 0.283 and 0.452,P<0. 05 and 0.01),while K was negatively correlated with Fib and PLT( r =-0.254 and-0. 354,P =0. 041 and 0.046),and Angle was positively correlated with Fib and PLT( r = 0.267 and 5.362,P = 0.027 and 0. 002),and MA was positively correlated with Fib and PLT( r = 0.536 and 0.755,P<0. 001). Conclusion Use of thrombelastogram at 48 h after successful cardiopulmonary resuscitation may provide reliable basis for patients with anti-platelet drug in early period.更多还原