【摘要】 目的探讨舒肝宁注射液与5%葡萄糖注射液配伍的稳定性。方法舒肝宁注射液依照临床使用的质量浓度与5%葡萄糖注射液配伍。依照《中国药典》的方法分别检测成品溶液放置0、2、4、6 h后的外观、pH值、不溶性微粒数量的变化,同时采用HPLC检定成品溶液中绿原酸、栀子苷、黄芩苷、黄芩素、野黄芩苷的含量。结果成品溶液的外观、pH值、各有效成分含量于6 h内无明显的变化;不溶性微粒数量于4 h内基本符合标准,但6 h内其数量是逐渐增加。结论舒肝宁注射液与5%葡萄糖注射液配伍在4 h内稳定。更多还原

【Abstract】 OBJECTIVE To study the stability of ShuGanNing injection combined with 5% Glucose Injection.METHODS ShuGanNing injection were mixed with 5% Glucose injection according to mass concentration in the clinic respectively.According to Chinese Pharmacopeia,the fluid compatibility testing of the appearance,value of pH,insoluble particles were performed at 0,2,4,6 h after the preparation.Chlorogenic acid,geniposide,scutellarin,baicalin,baicalein were deter mined by HPLC.RESULTS The appearance,pH,and active ingredient content of finished produce show no maked change within 6 h.The amount of insoluble granule in finished fluid is standard within 4 h.And the amount of insoluble granule in finished fluid continued to increase within 6 h.CONCLUSION The compatibility of Shuganning Injection with 5% Glucose Injection is stable within 4 h.更多还原