【摘要】 <正>手术部位感染是脊柱手术后常见且非常严重的并发症,严重影响患者的身体健康。尽管手术操作无菌细致,及时给予适当的全身抗生素,但手术部位感染率仍然很高^[1-2]。据报道,我国脊柱手术感染的风险从0.5%～7.8%不等^[3-4]。糖尿病、肥胖、高血压等疾病显著增加脊柱术后感染,感染后治疗的费用可达10多万美元^[5],大大增加了患者的经济负担。脊柱手术部位的感染菌主要是金黄色葡萄球菌,其次是表皮葡萄球菌^[6],更多还原

【Abstract】 Infection after spine surgery is a very serious complication,which may lead to severe nerve injury,even death.Frequent use of clinical instruments increases its incidence.This article summarizes the advantages and disadvantages of each animal model to unveil its effectiveness simulating the process and lack of all-round evaluation on real-time observation rather than simple bacterial culture and histological analysis at a certain point.The application of immunofluorescence has achieved long-term monitoring of bioluminescent bacterial infections.However,microbiology,imaging and histopathology will be combined for a comprehensive assessment.更多还原