【摘要】 目的比较鼓室内注射地塞米松联合静脉注射用药与其他治疗方法对突发性感音神经性聋疗效及预后的差异。方法对2017年1月～2019年9月在我院诊断突发性感音神经性聋并进行治疗的245例患者进行研究。所有患者均严格参照突发性聋诊断和治疗指南(2015)入组,分组包括常规静脉给药、单纯鼓室内注射地塞米松、静脉注射与鼓室内注射地塞米松联合应用。根据治疗前后恢复效果应用SPSS19.0统计软件对各组特征及疗效进行比较。结果常规静脉给药、单纯鼓室内注射地塞米松、静脉注射与鼓室内注射地塞米松联合应用中患者的性别、年龄、伴随症状、患病侧别、分型及严重程度比较差异均无统计学意义(P> 0.05)。三组间有效率比较差异有统计学意义(P <0.05),进一步两两比较发现突发性聋患者联合用药组有效率为90.29%,明显高于常规静脉给药组的71.67%及单纯鼓室内注射组的48.78%,进一步将不同分型的突聋患者有效率在各组间进行比较,显示高频下降型与平坦型患者的疗效有效率在各组间差异有统计学意义(P <0.05),联合用药组有效率高于常规静脉给药组及单纯鼓室内注射组;而低频下降型与全聋型患者的疗效有效率在各组间差异无统计学意义(P> 0.05)。结论鼓室内注射地塞米松与静脉注射联合用药比之单纯静脉给药及单纯鼓室内注射能显著提高治疗的有效率。更多还原

【Abstract】 Objective To compare the difference between the efficacy and prognosis of combined administration of intravenous injection and dexamethasone injection in the tympanic cavity with other therapeutic methods for sudden sensorineural deafness. Methods 245 patients with sudden sensorineural deafness diagnosed and admitted to our hospital from January 2017 to September 2019 were researched.All patients were strictly referred to the diagnosis and treatment guidelines for sudden deafness(2015) and were divided into groups,in which the routine intravenous administration group,the dexamethasone injection in the tympanic cavity alone group,and the combined administration of intravenous injection and dexamethasone injection in the tympanic cavity group were included.According to the recovery efficacy at baseline and post-treatment,SPSS19.0 statistical software was used to compare the features and curative effects of each group. Results There was no significant difference in sexes,ages,accompanying symptoms,diseased sides,types and severities among the routine intravenous administration group,the dexamethasone injection in the tympanic cavity alone group,and the combined administration of intravenous injection and dexamethasone injection in the tympanic cavity group(P > 0.05).Comparing the efficacy rates among the three groups showed that the differences among them were statistically significant(P=0.000 < 0.05).Further multiple comparisons showed that the efficacy rate of the combined administration group for sudden deafness patients was 90.29%,significantly higher than 71.67% of the routine intravenous administration group and 48.78% of the dexamethasone injection in the tympanic cavity alone group.Furthermore,the efficacy rates of different types of sudden deafness patients were compared among the treatment groups.The results showed that the efficacy rate of high frequency decreasing type and flat type patients was significantly different among the treatment groups(P=0.000< 0.05,and P=0.001 < 0.05,respectively).The efficacy rate of the combined administration group was higher than that of the routine intravenous administration group and the dexamethasone injection in the tympanic cavity alone group.However,there was no significant difference in the efficacy rate between the low frequency decreasing type and the total deafness type among the treatment groups(P > 0.05). Conclusion Combined administration of intravenous injection and dexamethasone injection in the tympanic cavity significantly improves the efficacy rate of treatment compared with intravenous injection or intratympanic injection alone.更多还原