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Detection of breast cancer based on novel porous silicon Bragg reflector surface-enhanced Raman spectroscopy-active structure

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【Author】 Xiaorong Ma;Hong Cheng;Junwei Hou;Zhenhong Jia;Guohua Wu;Xiaoyi Lü;Hongyi Li;Xiangxiang Zheng;Chen Chen;School of Physical Science and Technology, Xinjiang University;Affiliated Tumor Hospital of Xinjiang Medical University;Department of Engineering, China University of Petroleum-Beijing;School of Information Science and Engineering, Xinjiang University;School of Electronic Engineering, Beijing University of Posts and Telecommunications;Quality of Products Supervision and Inspection Institute;

【通讯作者】贾振红;吕小毅;

【机构】 School of Physical Science and Technology, Xinjiang University； Affiliated Tumor Hospital of Xinjiang Medical University； Department of Engineering, China University of Petroleum-Beijing； School of Information Science and Engineering, Xinjiang University； School of Electronic Engineering, Beijing University of Posts and Telecommunications； Quality of Products Supervision and Inspection Institute；

【摘要】 In this Letter, the surface-enhanced Raman scattering(SERS) signal of early breast cancer(BRC) patient serum is obtained by a composite silver nanoparticles(Ag NPs) PSi Bragg reflector SERS substrate. Based on these advantages, the serum SERS signals of 30 normal people and 30 early BRC patients were detected by this substrate. After a baseline correction of the experimental data, principal component analysis and linear discriminant analysis were used to complete the data processing. The results showed that the diagnostic accuracy, specificity,and sensitivity of the composite Ag NPs PSi Bragg reflector SERS substrate were 95%, 96.7%, and 93.3%, respectively. The results of this exploratory study prove that the detection of early BRC serum based on a composite Ag NPs PSi Bragg reflector SERS substrate is with a stable strong SERS signal, and an unmarked and noninvasive BRC diagnosis technology. In the future, this technology can serve as a noninvasive clinical tool to detect cancer diseases and have a considerable impact on clinical medical detection.更多还原

【Abstract】 In this Letter, the surface-enhanced Raman scattering(SERS) signal of early breast cancer(BRC) patient serum is obtained by a composite silver nanoparticles(Ag NPs) PSi Bragg reflector SERS substrate. Based on these advantages, the serum SERS signals of 30 normal people and 30 early BRC patients were detected by this substrate. After a baseline correction of the experimental data, principal component analysis and linear discriminant analysis were used to complete the data processing. The results showed that the diagnostic accuracy, specificity,and sensitivity of the composite Ag NPs PSi Bragg reflector SERS substrate were 95%, 96.7%, and 93.3%, respectively. The results of this exploratory study prove that the detection of early BRC serum based on a composite Ag NPs PSi Bragg reflector SERS substrate is with a stable strong SERS signal, and an unmarked and noninvasive BRC diagnosis technology. In the future, this technology can serve as a noninvasive clinical tool to detect cancer diseases and have a considerable impact on clinical medical detection.更多还原

【关键词】 porous silicon Bragg reflector； surface-enhanced Raman scattering； breast cancer detection； principal component analysis； linear discriminant analysis；
【Key words】 porous silicon Bragg reflector； surface-enhanced Raman scattering； breast cancer detection； principal component analysis； linear discriminant analysis；

【基金】 supported by the National Natural Science Foundation of China (Nos. 61665012,61575168,61765014);the International Science Cooperation Project of the Ministry of Education of the People’s Republic of China (No. 2016–2196);the Reserve Talents Project of National High-level Personnel of the Special Support Program (No. QN2016YX0324)

【文献出处】 Chinese Optics Letters ,中国光学快报(英文版) , 编辑部邮箱 ,2020年05期

【分类号】R737.9;O433
【被引频次】1
【下载频次】60

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