【摘要】 卵巢癌是致死率最高的妇科肿瘤,近年研究发现铁死亡与卵巢癌有密切关系。铁死亡是一种不同于凋亡、坏死的依赖于铁的细胞死亡形式,以细胞膜脂质过氧化物堆积为特点。铁死亡发生关键在于芬顿反应中活性氧的产生和谷胱甘肽过氧化物酶4的还原反应。目前有多种诱导剂和抑制剂调控铁死亡,使用药物诱导卵巢癌细胞发生铁死亡是卵巢癌治疗的新方向。深入探讨铁死亡机制、铁死亡相关药物及铁死亡在卵巢癌的新进展,为卵巢癌的治疗提供新策略。更多还原

【Abstract】 Ovarian cancer has the highest mortality among gynecologic malignancies. Studies in recent years have found that ferroptosis is closely related with ovarian cancer. Ferroptosis is an iron-dependent cell death mode different from apoptosis, necroiss and its particularity is lipid peroxide in cell membrane. The key to ferroptosis lies in the production of reactive oxygen species in Fenton reaction and the reduction of glutathione-dependant peroxidase 4. Currently, there are many inducers and inhibitors to regulate the ferroptosis. Using drugs to promote ferroptosis in ovarian cancer cells is a new treatment mode. The paper further discusses the mechanism of ferroptosis, drugs about ferroptosis and new developments of ferroptosis in ovarian cancer to provide new strategies for the treatment of ovarian cancer.更多还原