【摘要】 重组杆状病毒作为安全、可靠的基因治疗载体,在神经性疾病、心血管疾病以及恶性肿瘤的基因治疗中具有重要的应用价值。随着分子生物学技术日趋成熟,杆状病毒表达系统的研究使得该载体能够成功规避机体血液中补体系统的清除。另外,具有组织特异性的启动子也为实现各类重组病毒载体的靶向治疗发挥了重要的作用。该文对重组杆状病毒基因治疗载体的研究进行总结和阐述,以期对构建p53基因重组杆状病毒基因治疗载体提供文献依据,实现更安全、可靠、精准的基因治疗策略。更多还原

【Abstract】 Recombinant baculovirus as the safe and reliable gene treatment vector has an important application value in the gene therapy for neurological diseases,cardiovascular diseases and malignant tumors.With the maturity of molecular biology technology,the expression system of baculovirus enables the vector to successfully evade the elimination of complement system in blood.Otherwise,tissue-specific promoters also play an important role in targeted therapy of various recombinant viral vectors.This paper summarizes and expounds the research on recombinant baculovirus gene therapy vector,in order to provide the literature evidence for the construction of p53 gene recombinant baculovirus gene therapy vector and realize a safer,more reliable and more accurate gene therapy strategy.更多还原