【摘要】 目的研究新β细胞功能指数（MBCI）和维生素D联合评估2型糖尿病患者β细胞功能的可能性。方法回顾分析22例糖耐量正常者、31例2型糖尿病患者的口服葡萄糖耐量试验（OGTT）、胰岛素、维生素D、糖化血红蛋白,计算Homa-β胰岛素分泌指数（HBCI）、MBCI、ΔI₆₀/ΔG₆₀、Homa-胰岛素抵抗指数（HomaIR）。利用参数检验,线性回归分析维生素D与不同β细胞功能指数组合和血糖水平变化的相关性。结果维生素D与糖化血红蛋白不相关（r=-0.349,P>0.05）,维生素D与OGTT试验60min血糖(PG₆₀)、PG₁₂₀显著相关（r=-0.373、-0.408,均P<0.05）。以PG₁₂₀为因变量,分别以维生素D+HBCI、维生素D+MBCI、维生素D+ΔI₆₀/ΔG₆₀的组合为自变量做线性回归分析,所得模型相关指数R2分别为0.290、0.174、0.293;以HomaIR+HBCI、Homa-IR+MBCI、Homa-IR+ΔI₆₀/ΔG₆₀的组合为自变量做线性回归分析,所得模型相关指数R²分别为0.576、0.789、0.493;以Homa-IR+HBCI+维生素D、Homa-IR+MBCI+维生素D、Homa-IR+ΔI₆₀/ΔG₆₀+维生素D的组合为自变量做线性回归分析,所得模型相关指数R²分别为0.607、0.783、0.569。结论维生素D与PG₆₀、PG₁₂₀显著相关,但与MBCI的组合仅能解释一小部分血糖水平的变化。在评估2型糖尿病患者β细胞功能时,MBCI较其他β细胞功能指数更具可靠性,能解释更多的血糖变化。更多还原

【Abstract】 Objective To study the possibility of the modifiedβ-cell function index（MBCI）and vitamin D jointly evaluating β-cell function in patients with type 2 diabetes.Methods The oral glucose tolerance test（OGTT）,insulin,vitamin D,and glycated hemoglobin were retrospectively analyzed in 22 patients with normal glucose tolerance and 31 patients with type 2 diabetes,Homa-β insulin secretion index（HBCI）,MBCI,ΔI₆₀/ΔG₆₀,Homa-insulin resistance index（Homa-IR）were calculated.Parametric tests and linear regression were used to analyze the correlation between vitamin D and different β-cell function index combinations with changes in blood glucose levels.Results Vitamin D was not correlated with glycated hemoglobin（r=-0.349,P>0.05）,and it was significantly correlated with OGTT test 60 min blood glucose(PG₆₀)and PG₁₂₀（r=-0.373,-0.408,both P<0.05）.Linear regression analysis was performed using PG₁₂₀ as the dependent variable,and vitamin D+HBCI,vitamin D+MBCI,and vitamin D+ΔI₆₀/ΔG₆₀ as independent variables,the model correlation index R2 were 0.290,0.174,0.293,respectively;linear regression analysis was performed using Homa-IR+HBCI,Homa-IR+MBCI,Homa-IR+ΔI₆₀/ΔG₆₀ as independent variables,and the correlation index R² of the model were 0.576,0.789,0.493,respectively;linear regression analysis was performed using Homa-IR+HBCI+vitamin D,Homa-IR+MBCI+vitamin D,Homa-IR+ΔI₆₀/ΔG₆₀+vitamin D as independent variables,and the correlation index R² of the model were 0.607,0.783,0.569.Conclusion Vitamin D is significantly related to PG₆₀ and PG₁₂₀,but the combination with MBCI can only explain a small part of the changes in blood glucose levels.In assessingβ-cell function in patients with type 2 diabetes,MBCI is more reliable than other β-cell function indexes and can explain more blood glucose changes.更多还原