【摘要】 目的分析枸橼酸抗凝联合连续性肾脏替代治疗(CRRT)治疗急性肾损伤患者的疗效及对血清肌酸激酶同工酶(CK-MB)、血尿素氮(BUN)水平的影响。方法选择2016年1月至2018年6月在该院进行治疗的急性肾损伤并进行血液透析的患者112例作为研究对象,随机分为对照组(n=56)和观察组(n=56)。对照组采用肝素抗凝联合CRRT治疗,观察组采用枸橼酸抗凝联合CRRT进行治疗。对两组患者肝肾功能、炎症因子进行评估。结果治疗后,观察组患者血清肌酐、BUN、CK-MB、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、凝血酶时间(TT)、白细胞介素(IL)-1、IL-6、IL-10,肿瘤坏死因子-α(TNF-α)均显著低于对照组,差异有统计学意义(均P<0.05)。结论枸橼酸联合CRRT能够提高血液净化效率,维持机体凝血功能正常,抑制炎性反应,具有较好的临床应用价值。更多还原

【Abstract】 Objective To analyze the efficacy of citrate anticoagulation combined with continuous renal replacement therapy(CRRT)in patients with acute kidney injury and its effect on serum creatine kinase isozyme(CK-MB)and blood urea nitrogen(BUN)levels.Methods A total of 112 patients with acute kidney injury who were treated in the hospital from January 2016 to June 2018 and undergoing hemodialysis were selected as the research subjects,and were randomly divided into the control group(n=56)and the observation group(n=56).The control group was treated with heparin anticoagulation combined with CRRT,and the observation group was treated with citrate anticoagulation combined with CRRT.Liver and kidney function and inflammatory factors were evaluated in two groups of patients.Results After treatment,patients in the observation group had serum creatinine,BUN,CK-MB,alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum prothrombin time(PT),activated partial thrombin time(APTT),thrombin time(TT),interleukin(IL)-1,IL-6,IL-10,and tumor necrosis factor-α(TNF-α)were significantly lower than those in the control group(all P<0.05).Conclusion Citric acid combined with CRRT can improve blood purification efficiency,maintain normal coagulation function of the body,and inhibit inflammatory response,which has good clinical application value.更多还原