【摘要】 雷诺现象是在寒冷或压力状态下由血管痉挛引起的指(趾)端的3阶段颜色反应,常伴疼痛、麻木、僵硬甚至溃疡。但其具体发病机制尚未明确,且尚无特定有效的治疗方法。随着研究的进展,A型肉毒毒素开始运用于治疗雷诺现象,且已证实A型肉毒毒素可以有效缓解雷诺现象患者的症状,包括疼痛缓解、血流改善、皮温升高,及溃疡愈合改善等。因此,A型肉毒毒素已经成为缓解雷诺现象严重血管痉挛症状的一种新手段,但其拮抗小动脉异常收缩的具体机制尚不明确。该文对雷诺现象的病理机制及A型肉毒毒素发挥作用的相关机制进行总结,为肉毒毒素治疗雷诺现象奠定理论基础。更多还原

【Abstract】 Raynaud’s phenomenon( RP) is a three-phase color change in the fingers and/or toes caused by vasospasm under cold or stress conditions and is often accompanied by pain,numbness,stiffness and even ulcers. The pathogenesis of RP is currently unclear,and specific treatments are still being explored. Botulinum neurotoxin type A( Bo NT/A) is a polypeptide produced by Clostridium botulinum that can enter the presynaptic membrane of nerves to inhibit the release of neurotransmitters and exert chemical denervation.Bo NT/A treatment has been shown to reduce pain,improve blood flow,increase skin temperature,and improve ulcer healing in RP patients. Therefore,Bo NT/A has become a new therapeutic measure for relieving severe vasospasm in RP. However,the specific mechanisms by which Bo NT/A antagonizes the abnormal contraction of small arteries are still unclear. This review is aimed to provide a summary of the current understanding of RP pathogenesis and the mechanism of action of Bo NT/A in order to provide theoretical support for the use of Bo NT/A as RP treatment.更多还原