【摘要】 目的分析认知功能训练联合脑循环治疗对轻度血管性痴呆(VD)的疗效及安全性。方法选取2017年1月～2017年12月上海中冶医院收治的轻度VD患者100例作为研究对象,随机均分为4组。对照组采用尼麦角林片和奥拉西坦胶囊治疗;治疗1、2、3组(T1组、T2组、T3组)在对照组基础上分别采用认知功能训练、脑循环治疗、认知功能训练联合脑循环治疗。比较各组治疗前、治疗4、8、12周时蒙特利尔认知评估量表(MoCA)评分、日常生活能力量表(ADL)评分、局部脑血流量(r CBF)及并发症的发生率。结果 T3组在接受治疗4、8、12周时MoCA评分明显高于治疗前及对照组,治疗8、12周时明显高于T1、T2组(P <0.05);T3组在治疗4、8、12周时ADL评分、r CBF水平均明显高于治疗前和其他3组(P <0.05);T1组、T2组、T3组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论药物治疗基础上,认知功能训练联合脑循环治疗,可明显改善轻度VD患者认知功能、日常生活能力和脑血流情况,安全且疗效更好。更多还原

【Abstract】 Objective To analyze the efficacy and safety of cognitive training combined with cerebral circulation on mild vascular dementia.Methods 100 mild vascular dementia patients in Shanghai Metallurgical Hospital from January 2017 to December2017 were randomly divided into 4 groups,25 cases in each group.The control group was treated with nicergoline tablets and oxiracetam capsules alone.The treatment group 1(T1) was treated with the drugs plus cognitive training.The treatment group 2(T2) was treated with the drugs plus cerebral circulation therapy.The treatment group 3(T3) was treated with the drugs plus cognitive training and cerebral circulation therapy.The score of Montreal Cognitive Assessment Scale(MoCA),activity of daily living scale(ADL),regional cerebral blood flow(r CBF) and complications before treatment,and at 4 weeks,8 weeks and 12 weeks after treatment were documented.Results The MoCA scores in group T3 at 4 weeks,8 weeks and 12 weeks after treatment were significantly higher than that before treatment and those in the control group,and the MoCA scores in group T3 were significantly higher than those in group T1 and group T2 at 8 weeks and 12 weeks after treatment(P < 0.05).The ADL scores and r CBF levels in group T3 at 4 weeks,8 weeks,and 12 weeks after treatment were significantly higher than those before treatment and those in the other 3 groups(P <0.05).There was no significant difference in the incidence of adverse reactions among 4 groups(P > 0.05).Conclusion Based on drug therapy,cognitive function training combined with cerebral circulation therapy might significantly improve the patients’ cognitive function,daily living ability and cerebral blood flow.It is safe and effective for patients with mild vascular dementia.更多还原