【摘要】 目的评价高原地区健康中老年人椎体骨量的变化规律。方法对130例50岁以上健康体检中老年人采用双能X射线骨密度仪（DEXA）测量椎体骨密度（BMD）值再行胸部多层螺旋CT（MSCT）扫描,测量T_10-12及L₁椎体CT值对2种方法的测量值进行相关性分析。将所有中老年人按年龄分为50～<55岁、55～<65岁、65～<87岁3组,比较各组间及同年龄组不同性别间CT值。结果 50～<55岁、55～<65岁组男、女T_10-12及L₁椎体CT值比较差异均无统计学意义（P>0.05）,65～<87岁组女性T_10-12及L₁椎体CT值均低于男性差异有统计学意义（P<0.05）;与50～<55岁组及55～<65岁组比较;65～<87岁组男、女T_10-12及L₁椎体CT值均明显降低差异有统计学意义（P<0.05或P<0.01）。BMD值与T_10-12及L₁椎体CT值呈显著正相关（P<0.01）相关系数r分别为0.630,0.585。结论中老年人椎体BMD随年龄增大而降低,年龄越大男、女性之间的差异越明显;MSCT是一种简便、价廉且能较为准确评价椎体BMD的方法。更多还原

【Abstract】 Objective To evaluate the changing rule of vertebral bone mass in healthy middle aged and elderly people in plateau area.Methods Totally 130 cases of healthy middle-aged and elderly people over 50 years old were given dual energy X-ray absorptiometry（DEXA） to measure the bone mineral density（BMD） value,followed by chest multi-slice spiral CT（MSCT） scan,and CT values of T_10-12 and L₁ vertebra were measured.Correlation analysis was carried out for the measured values of the 2 methods.All middle^-aged and elderly people were divided into 3 groups according to their ages:50-<55,55-<65 and 65-<87.The CT values of different groups and the same age group were compared.Results There was no significant difference in the CT values of T_10-12 and L₁ vertebra between men and women aged 50-<55 and 55-<65（P>0.05）.The CT values of T_10-12 and L₁ vertebra of women aged 65-<87 were lower than those of men（P<0.05）.Compared with the groups aged 50-<55 and 55-<65,the CT values of T_10-12 and L₁ vertebra of men and women group aged 65-<87 decreased significantly,and the difference was statistically significant（P<0.05 or P<0.01）.BMD value was positively correlated with T_10-12 and L₁ vertebra CT value（P<0.01）,and the correlation coefficients r were 0.630 and 0.585,respectively.Conclusion The BMD of vertebra in the elderly decreases with the increase of age.The older the age is,the more significant the difference between male and female is.MSCT is a simple,cheap and accurate method to evaluate vertebral BMD.更多还原