【摘要】 目的分析钆塞酸二钠(Gd-EOB-DTPA)增强磁共振成像(MRI)评估原发性胆汁性胆管炎(PBC)患者肝功能的可行性。方法 21例PBC患者(PBC组)和21例肝炎后肝硬化患者(对照组)进行Gd-EOB-DTPA增强MRI检查,比较两组肝脏相对增强度(RE)和胆总管对比噪声比(CNR)。结果相同Child-Pugh分级的PBC患者肝脏RE和胆总管CNR随GdEOB-DTPA注射后时间延长而增加(P<0.01),相同时间点肝脏RE和胆总管CNR随着Child-Pugh分级增加而降低(P<0.01)。不同Child-Pugh分级的PBC组和对照组患者在各时间点肝脏RE和胆总管CNR差异无统计学意义(P>0.05)。结论 Gd-EOB-DTPA增强MRI可用于评估PBC患者肝功能。更多还原

【Abstract】 Objective To investigate the feasibility of Gd-EOB-DTPA enhanced MRI in evaluating the liver function of primary biliary cholangitis(PBC).Methods Twenty-one patients with PBC(PBC group) and 21 with posthepatitic cirrhosis(control group) underwent Gd-EOB-DTPA enhanced MRI.The relative enhancement(RE) of liver and contrast noise ratio(CNR) of common bile duct were compared between two groups.Results Hepatic RE and common bile duct CNR were increased with Gd-EOB-DTPA injection time in PBC patients with same Child-Pugh grading,but they decreased with incremental Child-Pugh grading at same timepoint(P<0.01).After injecting Gd-EOB-DTPA,there was no significant difference in hepatic RE and common bile duct CNR between PBC group with different Child-Pugh grading and control group(P>0.05).Conclusion Gd-EOB-DTPA enhanced MRI is feasible to evaluate the liver function of PBC patients.更多还原