【摘要】 目的调查及分析重度低龄儿童龋(severe early childhood caries,S-ECC)患者中铁、锌、铜微量元素及维生素D的血清水平,为S-ECC儿童的一级预防及诊疗提供参考。方法选取2018年6月～2019年6月就诊于新疆医科大学健康管理中心儿童保健科儿童(3～5岁)184例,分为无龋组(caries free,CF)(n=89)和S-ECC组(n=95),抽血检测其铁、锌、铜3项微量元素及25羟维生素D的含量。结果 CF组与S-ECC组铁的血清含量为(8.36±0.42)mmol/L、(8.13±0.44)mmol/L,差异有统计学意义(t=3.50,P <0.001);锌的血清含量为(83.18±7.28)μmol/L、(79.23±6.38)μmol/L,差异有统计学意义(t=3.92,P <0.001);25羟维生素D的血清含量为(86.72±15.83)nmol/L、(77.75±11.38)nmol/L,差异有统计学意义(t=4.42,P <0.001);铜的血清含量为(20.18±4.84)μmol/L、(19.49±4.62)μmol/L,但差异无统计学意义(t=0.97,P=0.33)。结论 S-ECC患者血清中铁、锌及维生素D的含量较低,提示在S-ECC的防治过程中应重视铁、锌及维生素D的补充。更多还原

【Abstract】 Objective The serum levels of iron, zinc, copper and vitamin D in severe early childhood caries (S-ECC) patients were investigated and analyzed to provide reference for primary prevention and diagnosis of S-ECC children.MethodsA total of 184 children were enrolled in the Children Health Department of Xinjiang Medical University Health Management Center from June 2018 to June 2019. They were divided into the caries-free(CF) group(n=89) and S-ECC group(n=95). The contents of iron, zinc, copper and vitamin D were detected.ResultsThe serum iron content of the CF group and S-ECC group was(8.36 ± 0.42) mmol/L and(8.13 ± 0.44) mmol/L, respectively, and the difference was statistically significant(t=3.50, P < 0.001); the serum content of zinc was(83.18 ± 7.28) μmol/L and(79.23 ± 6.38) μmol/L, respectively, and the difference was statistically significant(t=3.92, P < 0.001); the serum content of 25-hydroxyvitamin D was(86.72 ± 15.83) nmol/L and(77.75 ± 11.38) nmol/L, respectively, and the difference was statistically significant(t=4.42, P < 0.001). The serum copper content of CF group and S-ECC group was(20.18 ± 4.84) μmol/L and(19.49 ± 4.62) μmol/L, but the difference was not statistically significant(t=0.97, P=0.33).ConclusionThe contents of iron, zinc and vitamin D in the serum of S-ECC patients are low, suggesting that iron, zinc and vitamin D supplementation should be emphasized in the prevention and treatment of S-ECC.更多还原