【摘要】 牙髓再生是牙体牙髓领域的研究热点,再生牙髓血运重建是牙髓再生的瓶颈,而所应用的支架材料又是血运重建的关键,本文对促进再生牙髓血运重建的支架材料作一综述。文献复习结果表明,牙髓血运重建所用支架材料的来源不同,主要有天然、人工合成和复合材料等。应用于血管再生的天然支架材料包括壳聚糖、透明质酸、细菌纤维素、原花青素等;人工合成支架材料包括水凝胶、冷冻凝胶、电纺丝等。具有双层管状结构的仿生复合支架系统具有低免疫原性和良好的生物相容性。适合根管形态的仿生细胞外基质的支架材料如可注射水凝胶/微球的研究推动了牙髓再生研究的发展,即根管内分布均匀的支架材料促进了牙髓样组织的生成;但新生的牙髓组织是否能够通过根尖孔建立有效的血液循环仍是一个巨大挑战。更多还原

【Abstract】 Endothelial regeneration is a research hotspot in the field of dental pulp. The regeneration of endodontic blood flow is the bottleneck of dental pulp regeneration, and the applied scaffold material is the key to revascularization.Stent materials were reviewed. The literature review results show that, depending on the source of the stent material used for endodontic revascularization, there are mainly natural, synthetic and composite materials. The natural scaffold materials used for vascular regeneration include chitosan, hyaluronic acid, bacterial cellulose, and proanthocyanidin; artificial scaffold materials include hydrogel, cryogel, and electrospinning. The bionic composite scaffold system with a double-layer tubular structure is low immunogenicity and good biocompatibility. Studies on the scaffold materials of bionic extracellular matrix, such as injectable hydrogels/microspheres, have promoted the development of dental pulp regeneration, that is, uniformly distributed scaffold materials in the root canal promote the generation of pulp-like tissue;Whether dental pulp tissue can establish effective blood circulation through the apical foramen remains a great challenge.更多还原