【摘要】 手性过渡金属催化剂催化的不对称氢化反应是制备光学纯手性氨基酸、手性醇、手性胺和手性酸等手性化合物的重要手段和途径.本文主要概括了近20年内中国科学家在手性膦配体及其过渡金属催化剂的设计合成及不对称催化氢化新反应两方面的研究进展,并展望了该领域的发展前景.更多还原

【Abstract】 Chiral transition metal complexes-catalyzed asymmetric hydrogenation is one of the most efficient methods for the synthesis of optically pure compounds including amino acids,alcohols,amines and acids,and has been intensively investigated in the past several decades. This review mainly summarizes the main progress of the transition metal-catalyzed asymmetric hydrogenation achieved by Chinese scientists from two aspects:(1)the design and synthesis of chiral phosphorus ligands and their transition metal catalysts;(2) catalytic asymmetric hydrogenations of new and difficult substrates including functionalized olefins,ketones,imines and heteroaromatic compounds. In addition,the challenges and prospects in the field of asymmetric hydrogenation are briefly discussed.更多还原