【摘要】 以（E）-5,9-二甲基-4,8-癸二烯酸乙酯为原料,发展了一种合成5,5,8aβ-三甲基-6β-羟基-反八氢-1-萘酮（1）的新方法,并将其成功应用于phenylspirodrimane类混源萜天然产物骨架的构建.对合成过程中所涉及的关键反应如区域选择性环氧化和Cp₂TiCl催化的自由基串联环合反应进行了优化.所合成化合物的结构均通过核磁共振波谱（NMR）和高分辨质谱（HRMS）进行了表征和确认.更多还原

【Abstract】 Starting from ethyl（E）-5,9-dimethyldeca-4,8-dienoate,we developed a method for the synthesis of 6β-hydroxy-5,5,8aβ-trimethyloctahydronaphthalen-1-one（1）,which was successfully applied to the establishment of the skeleton of phenylspirodrimane meroterpenoid natural products. Key steps such as regioselective epoxidation and Cp₂TiCl-promoted radical cascade cyclization have been optimized. The structures of the compounds synthesized have been characterized with nuclear magnetic resonance spectroscopy（ NMR） and high resolution mass spectrometry（ HRMS）.更多还原