【摘要】 缺血再灌注损伤是肝脏手术术后发生肝功能衰竭的重要原因。七氟烷是一种无色澄明易流动易挥发的液体,对气道的刺激作用小,可以使麻醉诱导和觉醒过程平稳而迅速,麻醉深度容易调节。具有溶解度低、血流动力学稳定性好、吸收和清除迅速等优点,已成为成人和儿童患者的院内手术及门诊手术最常用的吸入麻醉药。随着国内外临床试验和动物实验的研究不断地深入,各种挥发性麻醉剂对心、肝、肾、肺等器官的保护作用不断显现出来,起保护作用以七氟烷最为显著,而起到保护作用的两个主要环节分别是抗炎以及抗缺血再灌注损伤。本文就近年来七氟烷降低肝脏缺血再灌注损伤的相关机制研究进展进行综述。更多还原

【Abstract】 Ischemia-reperfusion injury is an important cause of liver failure after liver surgery. Sevoflurane is a new type of halogen inhaled anesthetic. It is a colorless, clear, easy-to-flow, volatile liquid with little irritation to the airway. It can make the induction and arousal process smooth and rapid, and the depth of anesthesia is easy Adjustment. It has the advantages of low solubility, good hemodynamic stability, rapid absorption and removal, etc. It has become the most commonly used inhalation anesthetic in hospital and outpatient surgery for adults and children. With the continuous deepening of clinical trials and animal experiments at home and abroad, the protective effects of various volatile anesthetics on the heart, liver, kidney, lung and other organs have continuously emerged. The most significant protective effect is sevoflurane. The two main links of protection are anti-inflammatory and anti-ischemia-reperfusion injury. This article reviews the recent research progress on the related mechanisms of sevoflurane in reducing liver ischemia-reperfusion injury.更多还原