【摘要】 目的:探讨乳腺导管原位癌(DCIS)的钼靶X线特征,分析其与病理核分级、人类表皮生长因子受体(HER2)、雌激素受体(ER)、孕激素受体(PR)表达的相关性。方法:回顾分析经手术病理证实的DCIS患者113例,均做乳腺X线检查,观察病变X线影像特征,并分析其影像表现与病理核分级及不同肿瘤因子表达的相关性。结果:①影像表现:113例中出现钙化85例(75.2%),其中不对称影或肿块或结构扭曲伴钙化占多数共72例,单纯钙化13例;单纯肿块11例(9.7%),不对称影和结构扭曲影14例(12.4%),未见异常3例(2.7%)。②影像表现与病理因子表达:钙化为主要影像表现,钙化的形态、分布、数目在HER2阳性组、ER/PR阳性组和三阴组间表现有差异,具有统计学意义(P<0.05)。HER2阳性58例,以高级别DCIS为主,钙化为区段性分布,形态线状分枝状为主,数量以多发或大量为主,数目>30枚占多数;ER/PR阳性47例,以非高级别DCIS为主,钙化为区域性分布,形态微小圆点状为主,数量以少许钙化为主,数目<30枚占多数。结论:DCIS患者乳腺X线影像表现具有一定特征性,X线影像与肿瘤的一些分子生物学行为及病理因子表达有相关性,对患者早期诊断、临床治疗方法选择具有临床意义。更多还原

【Abstract】 Objective:To investigate molybdenum target X-ray features of mammary ductal carcinoma in situ(DCIS),and analyze its correlation with pathological nuclear grade,human epidermal growth factor receptor 2(HER2),estrogen receptor(ER),and progesterone receptor(PR) expression.Methods:Retrospective analysis of 113 patients with DCIS confirmed by surgical pathology,all undergoing mammography.To observe the X-ray image features of the lesion andanalyze the correlation between image features,pathological nuclear grade and expression of different tumor factors.Results:①Image features:Of 113 cases,85 had calcification(75.2%).Among them,72 cases hadasymmetric shadow or mass or structural distortion with calcification,13 cases of simple calcification.Simple mass in 11 cases(9.7%).Asymmetric and structural distorted shadows in 14 cases(12.4%).No abnormality was found in 3 cases(2.7%).②Imaging manifestations and expression of pathological factors:calcification is the main imaging performance.The morphology,distribution and number of calcification were different among HER2 positive group,ER/PR positive group and triple negative group,which is statistically significant(P<0.05).58 cases of HER2 positive,mainly high grade DCIS.with calcification sectional distribution and predominant linear branching The number of calcifications was mainly multiple or large and the number>30 is the majority.47 cases of ER/PR positive,mainly non-high-grade DCIS,calcification as regional distribution.The shape of small dots was dominant.The number of calcifications was mainly a few,and the number <30 is the majority.Conclusions:Mammographic X-ray findings of DCIS patients have certainfeatures,X-ray findings are correlated with some molecular biological behaviors and the pathological factors expression of tumors,It has clinical significance for the early diagnosis and selection of clinical treatment.更多还原