【摘要】 目的观察南平市部分地区女性感染人乳头状病毒(HPV)情况及其与宫颈病变的关系,为宫颈癌的筛查和防治提供流行病学资料。方法收集南平市2 928例妇科患者的基本资料,采集宫颈脱落细胞,采用凯普导流杂交技术行HPV亚型分型检测,分析HPV感染情况及其亚型分布并进行统计学分析。结果 2 928例患者中共检出HPV阳性者663例(22.64%);南平部分地区HPV阳性检出率高于全国常模、全国常模(农村)、厦门地区及福州地区(P<0.05),低于建阳地区和三明地区(P<0.05);≥61岁女性在该地区各年龄段中阳性检出率最高,第二高峰出现在21～30岁,HPV亚型多重感染主要分布在21～40岁;在HPV亚型感染中,52、16和58型是常见的HPV高危亚型。结论南平市部分地区女性HPV阳性检出率与其他地区比较,存在一定地域性差异。≥61岁和21～30岁女性是筛查HPV感染和子宫颈病变的重点人群,侧重关注当地女性宫颈鳞癌和腺癌的早期筛查和防治。加强青少年女性防护,根据年龄差异和易感类型针对性选择合适的预防性疫苗。更多还原

【Abstract】 Objective To investigate the prevalence of human papillomavirus(HPV) infection among women in some areas of Nanping City,and to provide epidemiological data for the screening and prevention of cervical cancer.Methods The basic data of 2 928 cases of gynecological patients in Nanping City were collected,the cervical exfoliated cells were collected,the HPV subtype was detected by Kaipu diversion hybridization,the infection and subtype distribution of HPV were analyzed,and the statistical analysis was carried out.Results Among 2928 patients,663 were positive for HPV,with an infection rate of 22.64%;women over 61 years old in this area had the highest positive rate in all age groups,the second peak occurred in 21～30 years old,and multiple HPV subtypes were mainly distributed in 21～40 years old;among HPV subtypes,types 52,16 and 58 were common high-risk HPV subtypes.Conclusion The positive rate of HPV in some areas of Nanping City was different from that in other areas.Women over 61 years old and 21～30 years old were the key groups for screening HPV infection and cervical lesions,focusing on the early screening and prevention of local women′s cervical squamous cell carcinoma and adenocarcinoma.We should strengthen the protection of young women,and select the appropriate preventive vaccine according to the age difference and susceptibility type difference.更多还原