【摘要】 目的探讨咽喉反流(laryngopharyngeal reflux,LPR)与广基型声带息肉和非广基型声带息肉的相关性,为临床有效治疗声带息肉提供依据。方法选取2018年9月～2019年9月于重庆医科大学第一附属医院耳鼻咽喉头颈外科声带息肉切除术患者99例,术前喉镜分为广基型声带息肉和非广基型声带息肉。通过反流症状指数量表(Reflux symptom index,RSI)和反流体征评分量表(Reflux finding score,RFS)初步诊断为LPR,比较广基型声带息肉与非广基型声带息肉人群咽喉反流率,并对可能影响广基型声带息肉的因素(性别、吸烟史、饮酒史、环境暴露、用嗓过度、年龄和声音嘶哑的病程)一并纳入统计。利用卡方检验与独立样本t检验先进行单因素分析,P<0.05为标准筛选出可能相关的因素,再进行多因素的Logistic 回归分析,P<0.05表示存在显著性差异。结果单因素分析为用嗓过度、环境暴露、年龄和声音嘶哑的病程差异均无统计学意义,LPR、性别、吸烟史、饮酒史可能与广基型声带息肉相关(P<0.05),多因素Logistic回归分析显示,饮酒史和LPR的差异有统计学意义,与广基型声带息肉的发生密切相关。结论 LPR和饮酒史不仅是声带息肉发病的相关因素,相比较非广基型声带息肉,LPR和饮酒史与广基型声带息肉之间存在更大相关性,是广基型声带息肉发生的危险因素。更多还原

【Abstract】 OBJECTIVE To explore the correlation between laryngopharyngeal reflux and broa d-based and non-broad-based vocal cord polyps,and to provide evidence for effective clinical treatment of vocal cord polyps.METHODS From September 1,2018 to September 1,2019,99 patients with vocal cord polypectomy were performed in the Department of Otolaryngology Head and Neck Surgery of the First Affiliated Hospital of Chongqing Medical University.According to the patient’s preoperative laryngoscope,it is divided into broad-based and non-broad-based vocal cord polyps,A preliminary diagnosis of LPR was performed using the Reflux Symptom Index>13 and the Reflux Finding Score Scale>7.The rates of LPR in the broad-based vs.non-broad-based vocal cord polyps populations were compared.Factors(gender,smoking,drinking,environmental exposure,excessive use of voice,age,and duration of hoarseness) that may affect the broad-based vocal cord polyps were included in the statistics.Chi-square test and independent sample t-test were used to perform univariate analysis first,and P<0.05 was used as a criterion to screen for possible related factors,and then multi-factor Logistic regression analysis was performed,taking P<0.05,indicating significant differences.RESULTS After univariate analysis,there were no statistically significant differences in the course of excessive voice,environmental exposure,age,and hoarseness(P>0.05).LPR,gender,smoking,and drinking may be related to broad-based vocal cord polyps(P<0.05).Followed by multi-factor Logistic regression analysis,only the P value of drinking and LPR was <0.05,the difference was statistically significant.CONCLUSION LPR is not only a related factor in the occurrence of vocal cord polyps.Compared with non-wide-band vocal cord polyps,there is a greater correlation between laryngo-reflux and broad-band vocal cord polyps,which is an independent risk for the occurrence of broad-band vocal polyps factor.更多还原