【摘要】 以纳米技术为基础,研制专用于种鸡且完全溶于水的复合维生素预混剂。根据罗氏制药公司推荐的种鸡维生素最佳需求量确定比例,用伪三元相图筛选和优化处方,使用水溶性载体辅美粉代替水,与脂溶性维生素和表面活性剂按一定比例混合来进行成乳,直到整个体系呈干燥的颗粒,然后向其中混入水溶性维生素,将整个体系混合均匀,得到复合维生素预混剂。用ZETA电位和透射电镜来鉴定,可溶于水的预混剂水相中粒径大小和形态分布是否达到纳米乳的条件;通过温度加速、光加速试验与可视性状观测,进而判断稳定性。结果研制的预混剂水相中粒子平均粒径是24.4 nm,分布均匀,成球形乳滴状,彼此不粘连,符合纳米乳的条件;以纳米技术为基础用水溶性基质所做的维生素A、D、E的含量也符合要求;在4、25、40℃条件下放置20 d,预混剂颜色无明显变化,依然干燥,无结块。结果表明,制备的复合维生素预混剂稳定性好,可完全溶于水,并且水相符合纳米乳性状。更多还原

【Abstract】 Based on nanotechnology,one kind of complex vitamin premix for breeding chickens,wihch is completely soluble in water was prepared.The vitamin ratio was defined according to Roche recommended vitamin optimal demand in breeders,and the prescription was screened and optimizated by pseudo-ternary phase diagram,water was replaced by water-soluble carrier Fu Mei powder,and nanoemulsion was preparated for fat soluble vitamins and surfactants mixed in a certain proportion,until the whole system as dry particles,and then water soluble vitamins were mixed evenly,compound vitamin premix was preparated.The emulsion was identified by ZETA potential and transmission electron microscopy,whether the size and shape distribution of water soluble premixes in water phase were satisfied with the nanoemulsion conditions,and the stability was judged by temperature acceleration test,light acceleration test and visual property observation.The results showed that the average particle size is 24.4 nm in water phase of premix,which has uniform distribution,fine grained and regularly shaped carbides,and with globular dropwise shape,and without stick to each other,it conformed to the conditions of nanoemulsion.The contents of vitamin A,D and E were meet criterion,the color of premix has no obvious change under 4,25 and 40 ℃ for 20 d,still dry and no caking.The results showed that the prepared vitamin premixer has good stability,could be completely soluble in water,and the water phase conforms to the characteristics of nanoemulsion.更多还原