【摘要】 目的探讨长治地区幽门螺杆菌分型以及致病抗体与上消化道疾病的关系。方法选取2019年1月至2019年6月于本院门诊就诊的743例患者为研究对象。所有患者均行14C呼气试验,明确幽门螺杆菌感染,再行胃镜+组织病理活检诊断,根据病理结果,将患者分为活动期慢性非萎缩性胃炎组(n=297)、慢性萎缩性胃炎组(n=69)、消化性溃疡组(n=67)、胃癌组(n=62)、非活动期慢性非萎缩性胃炎组(n=248)。比较各组幽门螺杆菌感染与分型情况,以及不同消化道疾病患者HpⅠ型抗体阳性情况。结果 743例患者中,HpⅠ型、Ⅱ型阳性率分别为56.39%和28.26%,二者比较差异无统计学意义。各组间CagA阳性率比较差异有统计学意义(P<0.05)。各组间VacA阳性率比较差异无统计学意义。各组间CagA、VacA同时阳性率比较差异有统计学意义(P<0.05)。结论上消化道疾病进展与幽门螺杆菌分型明显相关,正确分型对于指导临床用药、缓解疾病进展、降低抗生素滥用及减少耐药菌株出现非常必要,对临床具有指导意义。更多还原

【Abstract】 Objective To explore the relationship between Helicobacter pylori typing, pathogenic antibodies and upper digestive tract diseases in Changzhi area. Methods From January 2019 to June 2019, 743 patients in our outpatient clinic were selected as the research subjects. All patients underwent 14 C breath test to confirm H. pylori infection, and then underwent gastroscopy + histopathological biopsy diagnosis. According to the pathological results, the patients were divided into active chronic non-atrophic gastritis group(n=297), chronic atrophic gastritis Group(n=69), peptic ulcer group(n=67), gastric cancer group(n=62), non-active chronic non-atrophic gastritis group(n=248). Compare the infection and typing of Helicobacter pylori in each group, and the positive status of Hp Ⅰ antibody in patients with different digestive tract diseases. Results Among 743 patients,the positive rates of Hp Ⅰ and Ⅱ were 56.39% and 28.26%, respectively, and there was no statistically significant difference between the two. There was a statistically significant difference in the positive rate of CagA among the groups(P<0.05). There was no significant difference in the positive rate of VacA among the groups. The positive rates of CagA and VacA were compared among the groups, and the difference was statistically significant(P<0.05). Conclusion The progression of upper gastrointestinal disease is obviously related to Helicobacter pylori typing. Correct typing is necessary to guide clinical medication, alleviate disease progression, reduce antibiotic abuse and reduce the emergence of drug-resistant strains, and has clinical significance.更多还原