【摘要】 目的分析探讨18F-脱氧葡萄糖正电子发射计算机断层扫描(18F-FDG PET/CT)显像在评估鼻咽癌治疗后疗效的价值。方法选取2016年1月至2019年7月在本院接受治疗的鼻咽癌患者85例,在其接受治疗后应用18F-FDG PET/CT显像测评治疗效果。依据对残余病灶的测定方法分为PET/CT组与CT组,采用PET/CT方法进行检测的患者为PET/CT组,采用CT方法进行检测的患者为CT组。对比分析两组真阳性、真阴性、假阳性、假阴性、阳性预测值、阴性预测值、检出率。比较肿瘤周围纤维组织与复发肿瘤组织的SUV平均值。记录PET/CT检测鼻咽癌原位复发的特异性与敏感性。结果 85例患者在治疗后接受检查,其中有残余病变的患者49例,PET/CT阴性者23例,真阴性者19例,假阴性者4例;PET/CT阳性者26例,真阳性者19例,假阳性者7例,PET/CT组对患者治疗后的残余病灶的检出率明显高于CT组,差异具有统计学意义(P<0.05)。肿瘤周围纤维组织的SUV平均值显著低于复发肿瘤组织,差异具有统计学意义(P<0.05)。PET/CT检测鼻咽癌原位复发的特异性为86.67%,敏感性为87.50%。结论 18F-FDG PET/CT显像在评估鼻咽癌治疗后的治疗效果中有较高的临床应用价值,是检测鼻咽癌残余病灶与肿瘤复发的重要方法,值得在临床推广应用。更多还原

【Abstract】 Objective To evaluate the value of 18 F-FDG positron emission computed tomography(18 F-FDG PET/CT) imaging in evaluating the therapeutic effect of nasopharyngeal carcinoma(NPC) after treatment. Methods 85 patients with nasopharyngeal carcinoma received treatment in our hospital were selected as the study subjects from January 2016 to July 2019. After treatment, 18 F-FDG PET/CT imaging was used to evaluate the therapeutic effect. The patients were divided into PET/CT group and CT group according to the determination method of residual lesions. The patients who were detected by PET/CT method were in PET/CT group, and those who were detected by CT method were in CT group. The true positive, true negative, false positive, false negative, positive predictive value, negative predictive value and detection rate of the two groups were compared and analyzed. The average SUV values of fibrous tissues around tumors were compared with those of recurrent tumors. The specificity and sensitivity of PET/CT in detecting in situ recurrence of nasopharyngeal carcinoma were recorded. Results After treatment, 85 patients underwent CT examination, including 49 patients with residual lesions, 23 patients with negative PET/CT, 19 patients with true negative and 4 patients with false negative. 26 patients with positive underwent PET/CT examination, 19 patients with true positive and 7 patients with false positive. The detection rate of residual lesions in PET/CT group was significantly higher than that in CT group. The difference was statistically significant(P<0.05). The average value of SUV in fibrous tissue around tumors was significantly lower than that in recurrent tumors(P<0.05). The specificity and sensitivity of PET/CT in detecting in situ recurrence of nasopharyngeal carcinoma were 86.67% and 87.50%. Conclusion 18 F-FDG PET/CT imaging has high clinical value in evaluating the therapeutic effect of nasopharyngeal carcinoma after treatment. It is an important method to detect residual lesions and recurrence of nasopharyngeal carcinoma, and it is worth popularizing in clinic.更多还原