【摘要】 目的通过对心脏磁共振图像室间隔曲率的测量及相关推导和计算,验证心脏磁共振成像(CMR)在评价肺动脉高压中的可行性。材料与方法 16例经右心导管检查确诊的肺动脉高压患者,在行右心导管检查的3天之内进行心脏磁共振检查,得到患者的室间隔曲率半径及左心室游离壁的曲率Rc,两者求得曲率比Rp;评价Rc与Rp之间的线性关系,并求得其线性回归公式,再通过Yong-Laplace公式(transseptal/transmural pressure ratio,Rp)=PIvs/PFw可由(SBP-SPAP)/SBP计算得到SPAP值,对所得的SPAP值与右心导管检查的SPAP值进行BlandAltman分析检测其一致性。结果 Rc与Rp之间呈线性相关,其回归方程式为Rc=0.032×Rp+0.08,转换后得到公式:SPAP=SBP×(0.92-0.032×Rp),计算出的SPAP估计值与右心导管测量的SPAP实测值进行Bland-Al tman分析,显示SPAP估测值与实测值间具有良好的一致性。结论心脏磁共振检查可在形态学上通过测量室间隔的曲率间接评价肺动脉高压,可应用于肺动脉高压的诊断、疗效评估及评价预后。更多还原

【Abstract】 Objective To verify the feasibility of cardiacmagnetic resonance imaging in evaluation of pulmonary hypertension by septal curvature measurement. Methods A total of sixteen pulmonary hypertension patients who confirmed by cardiac catheterization examination undergo cardiac magnetic resonance in three days after taking cardiac catheterization. Obtain ventricular septal radius of curvature and the curvature of the left ventricular free wall Rc and get the ratio Rp between them. Evaluate the linear relationship between Rc and Rp and acquire the the linear regression formula. Through Yong-Laplace equation(transseptal/transmural pressure ratio, Rp)=PIvs/PFw and through(SBP—SPAP)/SBP SPAP can be obtained, analyze the calculated SPAP and the SPAP of cardiac catheterization examination to test the consistency. Results All experimental data meet the normal distribution, and the difference was statistically significant(P<0.05) between cardiac MRI of left ventricular function by echocardiography and left ventricular function parameters EDV, ESV, EF values, but cardiac MRI Left differences were not statistically significant(P>0.05) between the right ventricular function parameters EDV, ESV, EF value. Conclusion Cardiac magnetic resonance imaging can indirectly evaluate pulmonary hypertension by measuring the curvature of ventricular septum in morphology, and can be used in the diagnosis, curative effect evaluation and prognosis evaluation of pulmonary hypertension.更多还原