【摘要】 以吲哚布芬为先导化合物,利用拼合原理,设计了3个吲哚布芬酰胺化合物,以取代苯甲酸为起始原料,通过氯化反应、Bischler-Napieralski反应、还原反应等对其进行了合成。3个目标化合物结构均经MS、¹H NMR和¹³C NMR确证。通过Bron比浊法研究了其对AA、ADP诱导的血小板聚集的影响。化合物7c对AA、ADP诱导的血小板聚集的抑制作用均优于阿司匹林。更多还原

【Abstract】 Three indobufenamide compounds based on combination principles were designed. They were synthesized by reaction chlorination, Bischler-Napieralski reaction and reduction reaction with starting material substituted benzoic acid. The structures of three indobufenamide compounds were identified by MS, ¹H NMR and ¹³C NMR. The targets compounds were tested for antiplatelet aggregation induced by AA and ADP by Born turbidimetry method. The compound 7 c showed a better activity against AA and ADP inducing platelet aggregation than aspirin.更多还原