【摘要】 目的探讨慢性肾脏病(chronic kidney disease,CKD)合并轻度认知障碍(mild cognitive impairment,MCI)患者的中医证候分布规律及其与认知功能的关系。方法收集2017年5月—2018年12月就诊于中国中医科学院广安门医院肾病科门诊及住院的139例CKD合并MCI患者的临床资料,进行中医证候采集,采用蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)中文版评估认知功能,对中医证候与各项认知功能进行比较分析。结果患者中医证型分布:气血两虚证>瘀阻脑络证>湿浊害清证>肾精亏虚证。气血两虚证患者抽象评分、语言评分更低(Z=-2.046,P=0.041;Z=-2.108,P=0.035)。结论 CKD合并MCI患者气血两虚证占比最高,该证型患者更容易出现抽象功能及语言功能的损害。更多还原

【Abstract】 Objective To explore the distribution rules of traditional Chinese medicine(TCM)syndromes in patients with chronic kidney disease(CKD)and mild cognitive impairment(MCI)and their relationship with various cognitive functions.Methods The clinical data of 139 outpatients and inpatients from the Department of Nephrology of Guang’anmen Hospital, China Academy of Chinese Medical Sciences from May 2017 to December 2018 and TCM syndromes of them were collected.And the Montreal Cognitive Assessment Scale(MoCA)Chinese version was used to assess the cognitive functions which were compared with TCM syndromes.Results The distribution of TCM syndromes: syndrome of qi and blood deficiency> syndrome of blood stasis obstructing collaterals of brain> syndrome of dampness and turbidity damaging clearness> deficiency of kidney essence.The abstract score and language score of patients with deficiency of qi and blood were the lowest(Z=-2.046, P=0.041; Z=-2.108, P=0.035).Conclusion CKD patients complicated with MCI have the highest proportion of deficiency of both qi and blood, and patients with this syndrome are more likely to suffer from impairment of abstract function and language function.更多还原