【摘要】 目的比较唑来膦酸注射液与帕米膦酸二钠治疗晚期肺癌骨转移患者的临床疗效。方法根据治疗方法的不同将84例肺癌骨转移患者分为观察组和对照组,各42例。观察组患者采用唑来膦酸注射液进行治疗,对照组患者采用帕米膦酸二钠进行治疗。比较两组患者的止痛起效时间、止痛维持时间、临床疗效、疼痛情况和不良反应发生情况。结果治疗后,两组患者的止痛起效时间、止痛维持时间及疼痛总有效率比较,差异均无统计学意义(P﹥0.05)。两组患者均未发生重度不良反应。观察组中,恶心者17例,发热者7例,肌痛者12例,头痛者6例;对照组中,恶心者16例,发热者8例,肌痛者13例,头痛者7例。两组患者的不良反应发生情况比较,差异无统计学意义(P﹥0.05)。结论唑来膦酸与帕米膦酸二钠均可有效改善晚期肺癌骨转移患者的临床症状,且安全性均较高,但唑来膦酸具有剂量小、操作简单方便的优势,可提高患者依从性,值得临床推广。更多还原

【Abstract】 Objective To compare the clinical efficacy of zoledronic acid injection and pamidronate disodium in the treatment of advanced lung cancer patients with bone metastasis. Method A total of 84 patients with lung cancer bone metastasis were selected and divided into experimental group and control group according to distinguished treatment methods, with 42 patients in each group. The observation group was treated with zoledronic acid injection, and the control group was treated with pamidronate disodium. The onset of analgesic efficacy and duration of action, clinical efficacy, pain and adverse reactions were compared between the two groups. Result After treatment, there was no statistically significant difference in the analgesic onset time, analgesic duration time and the total response to pain between the two groups of patients(P>0.05). No serious adverse reactions occurred in the two groups of patients. In the observation group, there were 17 cases of nausea, 7 cases of fever, 12 cases of myalgia and 6 cases of headache; in the control group,16 cases of nausea, 8 cases of fever, 13 cases of myalgia and 7 cases of headache, and there was no significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05). Conclusion Both zoledronic acid injection and pamidronate disodium can effectively improve the symptoms of advanced lung cancer patients with bone metastases, and the safety is relatively high. However, zoledronic acid injection has the advantages of small dose, simple and convenient operation, and can improve compliance of patient, which is worthy of clinical promotion.更多还原