【摘要】 目的调查鼻咽癌同步放化疗患者癌因性疲乏水平在不同治疗阶段的动态变化情况,并分析其影响因素。方法采用便利抽样法选取245例鼻咽癌同步放化疗患者作为研究对象。采用纵向研究设计,分别在入院放疗前1天（T₀）、放疗2周末（T₁）、放疗4周末（T₂）及放疗6周末（T₃）4个时间点调查245例鼻咽癌同步放化疗患者癌因性疲乏、躯体疼痛、心理痛苦及社会支持水平,比较4次测量结果的差异并分析患者癌因性疲乏的影响因素。结果 T₀、T₁、T₂、T₃ 4个时间点鼻咽癌同步放化疗患者癌症疲乏量表（CFS）得分分别为（18.82±5.80）、（18.99±6.07）、（22.28±4.42）、（24.70±4.72）分,中重度疲乏发生率依次为71.2%、72.5%、92.3%、97.0%。治疗阶段、年龄、性别、每日睡眠时间、有无照顾者、疼痛程度、心理痛苦及社会支持是癌因性疲乏的影响因素。结论鼻咽癌同步放化疗患者癌因性疲乏普遍存在,且癌因性疲乏水平随着治疗进展呈不断上升趋势,临床医护工作人员应及时评估患者疲乏的动态变化情况,加强对鼻咽癌同步放化疗患者不同阶段的疲乏干预,以缓解其疲乏症状。更多还原

【Abstract】 Objective To investigate the dynamic changes of the level of cancer-related fatigue in patients with nasopharyngeal carcinoma treated with concurrent chemoradiotherapy at different treatment stages and analyze its influencing factors.Method The convenience sampling method was used to select 245 nasopharyngeal carcinoma patients undergoing concurrent chemoradiotherapy.A longitudinal study design was used to investigate 245 nasopharyngeal carcinoma patients undergoing concurrent chemoradiotherapy at four time points,one day before admission（T₀）,two weekends（T₁）,four weekends（T₂）,and six weekends（T₃）.Caused by fatigue,physical pain,psychological pain,and social support level,compared the differences between the four measurements and analyzed the influencing factors of cancer-related fatigue in patients.Result The scores of cancer fatigue scale（CFS） in patients with nasopharyngeal carcinoma concurrent chemoradiotherapy at T₀,T₁,T₂,and T₃ were（18.82±5.80） points,（18.99±6.07） points,（22.28±4.42） points,and（24.70±4.72）points.The incidence of moderate to severe fatigue was 71.2%,72.5%,92.3% and 97.0%,respectively.The results of the generalized estimation equation analysis showed that treatment stage,age,gender,daily sleep time,the presence or absence of caregivers,pain,psychological distress and social support were the influencing factors of cancer-related fatigue.Conclusion Cancer-related fatigue in patients with nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy is prevalent,and the level of cancer-related fatigue is continuously increasing with the progress of treatment.Clinical medical staff should evaluate the dynamic changes of patient fatigue in a timely manner,and strengthen the concurrent radiation of fatigue intervention at different stages of chemotherapy patients to relieve their fatigue symptoms.更多还原