【摘要】 目的探讨甘氨双唑钠辅助伽玛刀治疗颅内转移瘤的近期疗效及安全性。方法依据随机数字表法将116例颅内转移瘤患者分为观察组和对照组,每组58例。观察组患者采取甘氨双唑钠辅助伽玛刀治疗,对照组患者仅采取伽玛刀治疗。比较两组患者的近期疗效及不良反应发生情况。结果观察组患者的总有效率为86.21%,高于对照组的70.69%,差异有统计学意义(P﹤0.05)。治疗期间,两组患者皮肤反应、消化道反应、神经系统反应、血液系统反应、肝功能不全、肾功能不全的发生率比较,差异均无统计学意义(P﹥0.05)。结论甘氨双唑钠辅助伽玛刀治疗颅内转移瘤的近期疗效较好,安全性较高,建议在临床中推广。更多还原

【Abstract】 Objective To evaluate the short-term curative effects and safety of sodium glycididazole combined with gamma knife in the treatment of intracranial metastases. Method A total of 116 patients with intracranial metastases were included in the analysis and randomized according to a random number table as study group and control group, with58 cases in each. The patients in study group were treated with sodium glycadiazole combined with gamma knife radiosurgery, while those in the control group received gamma knife radiosurgery only. The short-term curative effects and adverse reactions of the two groups were compared. Result The overall response rate in study group was 86.21%, which was significantly higher than that of the control group at 70.69%(P<0.05). During the treatment, the incience of skin reaction, digestive tract reaction, nervous system reaction, blood system reaction, hepatic dysfunction and renal dysfunction were similar between the two groups(P>0.05). Conclusion Sodium glycidazole in combinaiton with gamma knife radiosurgery is effective against intracranial metastases in the light of short-term curative effect, with acceptable safety.更多还原