【摘要】 目的探讨急性脑梗死患者血压变异性和血清N端脑钠肽前体(NT-pro-BNP)的水平变化及其两者之间的关系。方法选取急性脑梗死患者78例作为脑梗死组,抽取56例为对照组,为本院同期非脑血管疾病患者;对比分析组间血压变异性、血清NT-pro-BNP水平;对比分析脑梗死组亚组间(脑梗死面积、脑梗死部位、是否合并高血压病、随访90d时的预后)血压变异性、血清NT-pro-BNP水平。结果脑梗死组血压变异性、血清NT-pro-BNP水平显著高于对照组(P<0.05);大面积脑梗死组和脑梗死死亡组患者血清NT-pro-BNP水平和24h收缩压变异系数、24h舒张压变异系数、白昼收缩压变异系数、白昼舒张压变异系数、夜间收缩压变异系数及夜间舒张压变异系数均分别明显高于非大面积脑梗死组与脑梗死存活组(P<0.01);脑梗死合并高血压病组血清NT-pro-BNP水平和24h收缩压变异系数、白昼收缩压变异系数、白昼舒张压变异系数、夜间收缩压变异系数及夜间舒张压变异系数均显著高于脑梗死且血压正常组(P<0.05);前循环供血区脑梗死组与后循环供血区脑梗死组的24h收缩压变异系数、24h舒张压变异系数、白昼收缩压变异系数、白昼舒张压变异系数、夜间收缩压变异系数及夜间舒张压变异系数均有明显差异(P<0.05)。血清NT-pro-BNP水平与血压变异性相关指标24h收缩压变异系数、24h舒张压变异系数、白昼收缩压变异系数、白昼舒张压变异系数、夜间收缩压变异系数及夜间舒张压变异系数等呈正相关(r=0.339,0.341,0.339,0.330,0.380,0.374,P<0.01)。结论急性脑梗死患者血压变异性和血清N端脑钠肽前体(NT-pro-BNP)的水平明显升高,且血清NT-pro-BNP水平与血压变异性有关。更多还原

【Abstract】 Objective To explore blood pressure variability and the serum N-terminal pro-brain natriuretic peptide(NT-pro-BNP)level changes and the relation between blood pressure variability and NT-proBNP level in patients with acute ischemic stroke.Methods 78 patients with acute ischemic stroke within 48 hours of onset and 56 cases in the control group were enrolled in this study.The blood pressure variability and the serum levels of NT-pro-BNP on admission,size of infarction,region of infarction,with hypertension or without hypertension,and prognosis of follow-up for 90 days were measured.Results Blood pressure variability and the serum levels of NT-pro-BNP were significantly higher in the acute ischemic stroke group than those in the control group(P<0.05),Blood pressure variability and the serum levels of NT-pro-BNP were significantly higher in patients with massive cerebral infarction group and death group than those in patients without the conditions(P<0.05).Compared with patients without hypertension group,Blood pressure variability and the serum levels of NT-pro-BNP were increased in the patients with hypertension group(P<0.05).Only blood pressure variability in anterior circulation cerebral infarction group was higher than that in posterior circulation cerebral infarction group(P<0.05).The relationship between NT-Pro-BNP and blood pressure variability was a positive linear correlation(r=0.339,0.341,0.339,0.330,0.380,0.374,P<0.01).Conclusion Blood pressure variability and the serum levels of NT-pro-BNP were increased after acute ischemic stroke.Blood pressure variability was correlation with the serum levels of NT-pro-BNP.更多还原