【摘要】 目的:分析我院严重药品不良反应(ADR)发生特点,为临床安全用药提供参考。方法:对我院2014年1月—2017年6月上报的89例严重ADR报告从患者性别、年龄、药品种类、给药途径、所涉及到的器官/系统及临床表现、对原疾患的影响和转归等方面进行分析评价。结果:89例严重ADR中,男44例,女45例;年龄> 60岁58例(65.17%);给药途径中,静脉滴注用药71例(79.78%);涉及10类药品,52个品种;引起ADR前5位的药品为脱水剂和抗肿瘤药物;ADR中血液系统损害34例(26.56%);导致病程延长46例(51.69%),病情加重35例(39.33%)。结论:合理用药是减少ADR发生的关键因素之一,重点加强严重ADR监测工作,降低用药风险,促进用药安全。更多还原

【Abstract】 Objective: To analyze the characteristics of serious adverse drug reactions(ADR) in our hospital, and to provide reference for clinical safe drug use. Methods: 89 case of serious ADR reports in our hospital from January 2014 to June 2017 were analyzed and evaluated in terms of gender, age, drug types,administration routes, organ/system involved, clinical manifestations, effect on original diseases and outcomes.Results: Of the 89 patients with serious ADR, there were 44 males and 45 females. 58 patients were over 60 years old(65.17%). In administration routes, 71 patients(79.78%) were treated by intravenous drip of drugs; 10 types of drugs and 52 varieties were involved. The disease courses of 46 patients(51.69%) were prolonged and the diseases of 35 patients(39.33%) were aggravated. Conclusion: Rational drug use is one of the key factors to reduce the occurrence of ADR. The monitoring of serious ADR should be strengthened to reduce the risk of drug use and promote drug safety.更多还原