【摘要】 目的:评价3种质子泵抑制药预防颈脊髓损伤(CSCI)患者应激性溃疡(SU)的临床效果、不良反应(ADR)与成本。方法:采用回顾性分析方法,选取我院2018年1～6月收治的CSCI患者131例,按用药方案不同分为3组,分别为泮托拉唑钠80 mg,ivd,qd、奥美拉唑钠40 mg,ivd,qd、兰索拉唑30 mg,ivd,bid。观察3组方案预防患者消化道出血的疗效、不良反应发生情况,并评价3种质子泵抑制药的经济性。结果:泮托拉唑、奥美拉唑、兰索拉唑预防CSCI患者SU的有效率依次为93. 2%,93. 8%,97. 4%,不良反应发生率依次为6. 8%,6. 2%,5. 1%,差异均无统计学意义(P> 0. 05)。以最小成本分析进行药物经济学评价,3种质子泵抑制药预防CSCI患者SU的经济性由高到低依次为泮托拉唑、奥美拉唑、兰索拉唑。结论:泮托拉唑、奥美拉唑和兰索拉唑预防CSCI患者SU的疗效和安全性均较好,但相较于其他两种药物,泮托拉唑经济性更优,临床医师可根据患者情况选择用药。更多还原

【Abstract】 Objective: To compare the clinical efficacy,ADR and cost of 3 PPIs in the prevention of stress ulcer( SU) after cervical spinal cord injury( CSCI). Methods: In a retrospective study,131 CSCI patients were selected from our hospital during January and June 2018,and then divided into 3 groups according to their medication. The patients were treated with pantoprazole( 80 mg,ivd,qd),omeprazole( 40 mg,ivd,qd) and lansoprazole( 30 mg,ivd,bid),respectively. The clinical efficacy,adverse drug reactions and economics were compared among the 3 groups. Results: The effective rate of pantoprazole,omeprazole and lansoprazole in preventing SU in the patients with CSCI was 93. 2%,93. 8% and 97. 4%,and the incidence of adverse reactions was 6. 8%,6. 2% and5. 1%,respectively without statistical significance( P > 0. 05). Taking the minimum cost analysis as the pharmacoeconomic evaluation,the economical efficiency of the 3 PPIs in preventing SU in the patients with CSCI from high to low order was pantoprazole,omeprazole and lansoprazole. Conclusion: Pantoprazole,omeprazole and lansoprazole all show good effectiveness and safety in the prevention of SU,while pantoprazole is more economical than the others,and clinicians may choose drugs according to patient’s conditions.更多还原