【摘要】 目的观察硝黄细辛贴治疗小儿肺炎喘嗽(痰热闭肺证)的临床疗效。方法患儿65例随机分为两组,均采用常规抗感染及对症治疗,治疗组给予硝黄细辛贴治疗,对照组予安慰剂贴,疗程17 d。结果与对照组比较,治疗组主要症状体征积分明显下降(P <0.05)。治疗组的住院时间,咳嗽、发热、肺部啰音持续时间等明显低于对照组(P <0.05),随访6个月内的发热和咳嗽次数也明显较少(P <0.05)。炎症指标方面,治疗组的白细胞介素-10(IL-10)、白细胞介素-17(IL-17)、转化生长因子-β1(TGF-β1)水平低于对照组(P <0.01或P <0.001)。结论硝黄细辛贴治疗小儿(痰热闭肺证)肺炎喘嗽疗效显著,可明显改善患儿的主要症状、体征及降低相关的炎症指标。更多还原

【Abstract】 Objective: To observe the clinical efficacy of Xiaohuang Xixin Application on phlegm-heat obstructing lungs pneumonia in children. Methods: 65 cases were randomly divided into the treatment group and the control group. The two groups were treated with conventional anti-infection and symptomatic treatment.The treatment group received Xiaohuang Xixin Application,the control group to placebo. Results: Compared with the control group,the scores of main symptoms and signs in the treatment group decreased significantly(P < 0.05).There was significant difference in hospitalization time,cough,fever,lung rale duration and so on between two groups(P < 0.05). Fever and cough in the followed up for 6 months were also significantly fewer(P < 0.05). As for inflammatory indicators,IL-10,IL-17,TGF-β1 levels of IL-10,IL-17 and TGF-β1 of the treatment group were lower than those of the control group(P < 0.01 or P < 0.001). Conclusion: The efficacy of Xiaohuang Xixin Application is obvious on phlegm-heat obstructing lungs pneumonia in children. It can significantly improve the main symptoms and signs of children and reduce the related inflammatory markers,worthy of clinical promotion.更多还原