【摘要】 目的:研究血液灌流串联血液透析治疗对终末期糖尿病肾病(ESDN)患者胰岛素抵抗、微炎症状态与营养指标的影响。方法:选取2016年1月-2018年12月本院收治的41例ESDN患者,按照治疗方法不同将其分为对照组20例和观察组21例。对照组进行单纯血液透析治疗,观察组进行血液灌流串联血液透析治疗。对比两组胰岛素抵抗、微炎症状态与营养指标。结果:治疗前,两组胰岛素抵抗指标、微炎症指标、营养指标比较,差异均无统计学意义(P>0.05);治疗后,观察组胰岛素抵抗指标、微炎症指标均低于对照组,营养指标高于对照组,差异均有统计学意义(P<0.05);观察组并发症发生率9.52%,低于对照组的40.00%,差异有统计学意义(X~2=5.159,P=0.023)。结论:ESDN患者采用血液灌流串联血液透析治疗,与单纯的血液透析进行对比,可以更加理想的改善患者的胰岛素抵抗、微炎症状态,并且对营养情况进行改善,整体的治疗效果更加理想,可降低患者治疗中的并发症,临床推广价值较为理想。更多还原

【Abstract】 Objective: To study the effects of blood perfusion combined with hemodialysis on insulin resistance, microinflammation and nutritional indicators in patients with end-stage diabetic nephropathy(ESDN). Method: A total of 41 patients with ESDN admitted to our hospital from January 2016 to December 2018 were selected. According to different treatment methods, they were divided into 20 cases of control group and 21 cases of observation group. The control group was treated with hemodialysis alone, while the observation group was treated with blood perfusion combined with hemodialysis. The insulin resistance, microinflammation and nutritional indicators were compared between the two groups. Result: Before treatment, insulin resistance, microinflammation and nutrition were compared between the two groups, the differences were not statistically significant(P>0.05). After treatment, insulin resistance and microinflammation in the observation group were lower than those in the control group, and nutritional indexes were higher than those in the control group, the differences were statistically significant(P<0.05). The incidence of complications in the observation group was9.52%, which was lower than 40.00% in the control group, the difference was statistically significant( X~2=5.159, P=0.023). Conclusion: Compared with hemodialysis alone, ESDN patients treated with blood perfusion combined with hemodialysis can improve insulin resistance and microinflammation more ideally, improve nutritional status, achieve better overall treatment effect, reduce the complications in the treatment of patients, and its clinical popularization value is ideal.更多还原