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慢性乙型肝炎及非酒精性脂肪性肝炎患者肝脏病理特征分析

Analysis of pathological characteristics on chronic hepatitis B and nonalcoholic steatohepatitis

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【作者】 朱永芬王进方家追吕芳芳

【Author】 ZHU Yong-fen;WANG Jin;FANG Jia-zhui;Department of Hepatology and infection,Shao Yifu Hospital Affiliated to Zhejiang University School of Medicine;

【通讯作者】 吕芳芳;

【机构】 浙江大学医学院附属邵逸夫医院肝病感染科浙江大学医学院附属邵逸夫医院病理科

【摘要】 目的:分析研究非酒精性脂肪性肝炎及慢性乙型肝炎患者肝脏病理特征。方法:选取经过病理证实的非酒精性脂肪性肝炎30例患者和慢性乙型肝炎22例患者为研究对象,将二者病理分解为界面性肝炎、小叶内炎症、汇管区纤维化、窦周纤维化4个特征进行分析。结果:慢性乙型肝炎组患者2级以上界面性肝炎发生率明显高于非酒精性脂肪性肝炎组(100%vs 10%,P<0.001),2级以上汇管区纤维化发生率明显高于非酒精性脂肪性肝炎组(77.2%vs 16.7%,P<0.001)。两组患者小叶内炎症的发生率没有明显差异。结论:慢性乙型肝炎组患者2级以上界面性肝炎和2级以上汇管区纤维化发生率明显高于非酒精性脂肪性肝炎组患者。

【Abstract】 Objective:To analyze the pathological features of nonalcoholic steatohepatitis and chronic hepatitis B.Methods:The incidence of Interfacial hepatitis over grade 2 and periportal fibrosis over grade 2 in chronic hepatitis B were significantly higher than nonalcoholic steatohepatitis group(100% vs 10% and 77.2% vs 16.7%, both P<0.001). There was no significant difference in the incidence of lobular inflammation between the two groups. Results:The incidence of Interfacial hepatitis and periportal fibrosis over grade 2 in the chronic hepatitis B were higher than in non-alcoholic steatohepatitis.Conclusion:The incidence of Interfacial hepatitis and periportal fibrosis over grade 2 in the chronic hepatitis B were higher than in non-alcoholic steatohepatitis.

【基金】 浙江省自然科学基金(No:LY15H030009)
  • 【文献出处】 中西医结合肝病杂志 ,Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases , 编辑部邮箱 ,2019年06期
  • 【分类号】R512.62;R575
  • 【下载频次】105
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