【摘要】 目的讨论七氟烷与异丙酚对患有结肠癌的老年患者术后肺部感染的影响。方法选取我院2016年2月至2018年2月老年结肠癌患者80例,分为实验组和对照组,每组40例。实验组采用异丙酚作为静脉麻醉维持药物;对照组采用七氟烷作为吸入麻醉维持药物。通过比较两组患者麻醉效果、肺部感染情况和白细胞介素-6(IL-6)及T淋巴细胞亚群数量变化情况,进而得出实验结论。结果实验组老年结肠癌患者的自主呼吸恢复时间、睁眼时间、拔管时间和应答时间均短于对照组,P<0.05,具有统计学意义。实验组肺部感染率低于对照组,P<0.05,差异有统计学意义。术后1d:实验组IL-6与对照组比较显著降低且P<0.05,实验组CD3~+、CD4~+、CD4~+/CD8~+与对照组相比均较低,P<0.05,差异有统计学意义。结论老年患者全麻术后易发生肺部感染,麻醉剂与结直肠手术患者术后肺部感染具有一定相关性,而加强麻醉剂与结直肠手术后肺部感染对比研究,有助于选取合理麻醉剂降低其对机体功能的干扰,减少手术后肺部感染,帮助患者安全度过围术期。更多还原

【Abstract】 Objective To investigate the effect of inhaled anesthetics sevoflurane and propofol on pulmonary infection in elderly patients with colon cancer after operation.Methods We selected 80 cases of colon cancer patients from February 2016 to February 2018 in our hospital,and divided into observation group and control group,40 cases in each group.Intravenous anesthetics Propofol and inhaled anesthetics sevoflurane were respectively applied to the observation group and the control group.We compared the anesthesia effect,Postoperative Pulmonary Infection and interleukin-6(IL-6)and T lymphocyte subgroups between the two groups.Results The spontaneous respiratory recovery time,open-eye time,extubation time and response time in trial group were shorter than those in control group(P<0.05),and the difference was statistically significant The lung infection rate of the observation group was lower than that of the control group(P<0.05),the difference was statistically significant.One day after operation,IL-6decreased significantly compared with the control group(P<0.05),The experimental group CD3~+,CD4~+,CD4~+/CD8~+compared with the control group P<0.05,the difference was statistically significant.Conclusion Pulmonary infection is easy to occur after the general anesthesia in elderly patients,and there is a certain correlation between the anesthetics and pulmonary infection in postoperative patients undergoing colorectal surgery.To strengthen the comparison of lung infection after anesthesia and colorectal surgery,it is helpful to select a reasonable anesthetic agent to reduce its pulmonary infection Interfere with the function of the body,reduce pulmonary infection after operation,and help patients to get through perioperative period safely.更多还原