【摘要】 为了研究葛根素、黄芩苷和盐酸小檗碱对肠毒素大肠杆菌(ETEC)生长及分泌毒素的影响,在ETEC菌液中加入终浓度为200μg/mL的葛根素,终浓度为1μg/mL的黄芩苷,以及终浓度为100μg/mL的盐酸小檗碱,检测葛根素、黄芩苷和盐酸小檗碱对ETEC生长情况、菌毛亚基蛋白FaeG以及毒力因子(STa、STb和LT) mRNA表达的影响,结果发现,葛根素、黄芩苷和盐酸小檗碱对ETEC的生长有一定的抑制作用,其中黄芩苷可显著抑制ETEC分泌外毒素。更多还原

【Abstract】 In order to study the effects of puerarin,baicalin and berberine hydrochloride on the regulation of ETEC,puerarin(200 μg/mL),baicalin(1 μg/mL) and berberine hydrochloride(100 μg/mL) were used to detect the growth of ETEC,Fae G and enterotoxin(STa、STb and LT toxins) mRNA expressions.The results showed that puerarin,baicalin and berberine hydrochloride inhibited the growth of ETEC at short time,and baicalin significantly inhibited the secretion of ETEC exotoxins.更多还原