【摘要】 【目的】探讨常规浓度(5 g/L)、常规作用时间(3 min)下安尔碘Ⅲ型消毒剂术前结膜囊冲洗的消毒效果,及对眼表泪膜功能和结膜杯状细胞的影响,为内眼手术术前结膜囊消毒液的安全性及有效性提供临床依据。【方法】收集白内障超声乳化联合人工晶体植入手术患者30人30只患眼作为研究对象,比较安尔碘Ⅲ型消毒剂常规结膜囊冲洗前及冲洗后的结膜囊分泌物细菌培养情况;术前1 d、术后7和30 d进行Schirmer试验;眼表分析仪检测泪膜破裂(首次及平均)时间、泪河高度;共聚焦显微镜观察结膜杯状细胞的密度。【结果】冲洗前结膜囊分泌物细菌培养阳性3例、冲洗后无阳性检出,前后检出差异无统计学意义;术后7、30 d的泪液分泌与术前1 d比较差异无统计学意义;术后7、30 d的泪河高度与术前1 d比较差异无统计学意义;术前1 d与术后7 d的首次泪膜破裂时间比较差异有统计学意义(P <0.05)、与术后30 d的比较差异无统计学意义;术前1 d与术后7 d的平均泪膜破裂比较差异有统计学意义(P <0.05)、与术后30 d的比较差异无统计学意义;术前1 d与术后7 d的结膜杯状细胞密度比较差异有统计学意义(P <0.05)、与术后30 d的比较差异无统计学意义。【结论】安尔碘Ⅲ型消毒剂结膜囊冲洗可清除结膜囊的细菌;术后7 d内由于结膜杯状细胞密度减少对泪膜的稳定性有一定影响,术后30 d结膜杯状细胞密度恢复至术前水平,眼表泪膜功能恢复正常。更多还原

【Abstract】 【Objective】To evaluate the effect of preoperative conjunctival sac irrigation with Anerdian Ⅲ disinfectant and its effect on the function of eye surface and tear film.【Methods】This clinical study was involved of thirty cases(30 eyes)undergoing phacoemulsification. Conjunctiva sac irrigation with Anerdian disinfectant(type III,5 g/L)was performed before the phacoemulsification procedure. Secretions of conjunctiva sac were examined by bacterial culture pre-and post-irrigation. Schirmer test,non-invasive first tear break-up time(NITBUT-F),non-invasive average tear break-up time(NITBUT-A),tear meniscus height(TMH),and goblet cell density(GCD)were also evaluated day 1 before and day 7,day 30 after operation.【Results】3 cases were positive in bacterial culture pre-irrigation,while all were negative post-irrigation. There was no significantly change between Schirmer test and TMH from day 1 before,day7 and day 30 after operation. NITBUT-F,NITBUT-A,and GCD were significantly different between day 1 before and day 7 after operation(P<0.05),and shown no significantly difference between day 1 before and day 30 after operation.【Conclusions】Our results suggested that conjunctiva sac irrigation with Anerdian disinfectant was efficient,while it might be related to the decrease of GCD and dysfunction of tear film. However,GCD would gradually improve as preoperation and function of tear film could restore to normal.更多还原