【摘要】 目的研究分析对大脑中动脉狭窄引起的急性脑梗死患者采取氯吡格雷联合前列地尔治疗的临床疗效及安全性。方法 130例大脑中动脉狭窄引起的急性脑梗死患者,随机分为观察组与对照组,每组65例。对照组应用前列地尔治疗,观察组应用氯吡格雷联合前列地尔治疗,观察并对比两组患者治疗前后神经功能改善情况,并对比两组疗效和不良反应发生情况。结果治疗前,观察组日常生活能力量表(ADL)评分、美国国立卫生研究院卒中量表(NIHSS)评分分别为(37.94±4.01)、(18.85±5.49)分,对照组ADL评分、NIHSS评分分别为(37.85±3.96)、(19.02±5.52)分,两组对比差异无统计学意义(P>0.05);治疗后,观察组ADL评分、NIHSS评分分别为(73.15±6.87)、(8.71±2.25)分,对照组ADL评分、NIHSS评分分别为(62.03±5.64)、(13.87±3.45)分,两组均优于治疗前,且观察组优于对照组,差异具有统计学意义(P<0.05)。观察组治疗总有效率为95.38%,高于对照组的78.46%,差异具有统计学意义(P<0.05)。观察组不良反应发生率为7.69%,对照组不良反应发生率为6.15%,两组对比差异无统计学意义(P>0.05)。结论氯吡格雷联合前列地尔治疗大脑中动脉狭窄引起的急性脑梗死具有显著疗效,可有效促进患者神经功能的恢复、改善患者临床症状,且安全性高,值得大力推广。更多还原

【Abstract】 Objective To study and analyze the clinical efficacy and safety of clopidogrel combined with alprostadil in the treatment of acute cerebral infarction caused by middle cerebral artery stenosis. Methods A total of 130 patients with acute cerebral infarction caused by middle cerebral artery stenosis were randomly divided into observation group and control group, with 65 cases in each group. The control group was treated with alprostadil,and the observation group was treated with clopidogrel combined with alprostadil. Observation and comparison were made on improvement of neurological function before and after treatment, efficacy and adverse reactions of the two groups. Results Before treatment, the observation group had activities of daily living(ADL) score and National Institutes of Health Stroke scale(NIHSS) score respectively as(37.94±4.01) and(18.85±5.49) points,which were(37.85±3.96) and(19.02±5.52) points respectively in the control group, and their difference was not statistically significant(P>0.05). After treatment, the observation group had ADL and NIHSS score respectively as(73.15±6.87) and(8.71±2.25) points, which were(62.03±5.64) and(13.87±3.45) points in the control group.Both groups were better than those before treatment, and the observation group was better than the control group.Their difference was statistically significant(P<0.05). The observation group had higher total treatment effective rate as 95.38% than 78.46% in the control group, and the difference was statistically significant(P<0.05). The observation group had incidence of adverse reactions as 7.69%, which was 6.15% in the control group, and the difference was not statistically significant(P>0.05). Conclusion Clopidogrel combined with alprostadil shows significant efficacy in the treatment of acute cerebral infarction caused by middle cerebral artery stenosis, and can effectively promote the recovery of neurological function, improve the clinical symptoms of patients with high safety. It is worthy of vigorous promotion.更多还原