【摘要】 目的:比较腹腔镜胰十二指肠切除（LPD）与开腹胰十二指肠切除（OPD）治疗十二指肠乳头腺癌的近期及远期疗效。方法:回顾性分析2012年1月—2017年12月共89例行胰十二指肠切除术的十二指肠乳头腺癌患者的临床资料。其中50例行OPD,39例行LPD,比较两组患者的相关临床资料。结果:两组患者一般资料具有可比性。两组手术时间与术中输血例数无明显差异（均P>0.05）,但LPD组术中出血量明显少于OPD组（P<0.05）。LPD组术后住院时间明显短于OPD组（P<0.05）,但两组术后各并发症发生率、二次手术率、术后30 d死亡方面均无明显差异（均P>0.05）。两组R₀切除率及其他术后病理结果均无明显差异（均P>0.05）。两组1、3年总生存率与无病生存率均无明显差异（均P>0.05）。结论:与OPD比较,LPD治疗十二指肠乳头腺癌患者具有相同的肿瘤根治性,且不增加并发症的发生率,两者远期疗效也相似。更多还原

【Abstract】 Objective:To compare the short-and long-term efficacy of laparoscopic pancreaticoduodenectomy(LPD) and open pancreaticoduodenectomy(OPD) in treatment of adenocarcinoma of the papilla of Vater.Methods:The clinical data of 89 patients w ith carcinoma of the papilla of the Vater undergoing pancreaticoduodenectomy from January 2012 to December 2017 were retrospectively analyzed.Of the patients,50 cases underwent OPD and 39 cases underwent LPD.The main clinical variables between the two groups of patients were compared.Results:The general data were comparable between the two groups of patients.There were no significant differences in operative time and cases requiring intraoperative blood transfusion between the two groups(both P>0.05),but the intraoperative blood loss in LPD group was significantly less than that in OPD group(P<0.05).The length of postoperative hospital stay in LPD group was significantly shorter than that in OPD group(P<0.05),but the incidence rate of each postoperative complication,re-operation rate and postoperative 30 d death rate showed no significant differences between the two groups(all P>0.05).The R0 resection rates and other postoperative pathological results showed no significant difference between the two groups(all P>0.05).There were no significant differences in 1-,3-and 5-year overall survival rates and disease-free survival rates between the two groups(all P>0.05).Conclusion:In treatment of adenocarcinoma of the papilla of Vater,LPD offers the same oncological radicalness as OPD,without increase of complications,and the long-term outcomes of the two procedures are also similar.更多还原