【摘要】 目的探究经皮电刺激(transcutaneous electrical nerve stimulation, TENS)治疗对功能性消化不良上腹痛综合征患儿的胃肠道症状改善作用。方法选取2015年6月—2017年6月在鄂州市中心医院接受诊治的功能性消化不良上腹痛综合征患儿94例,随机分为刺激组和对照组,每组47例。刺激组行TENS治疗,对照组行常规治疗。结果治疗前,2组患儿各症状指标比较差异无统计学意义(P>0.05),治疗后,2组患儿各症状指标均一定程度改善,刺激组症状恢复程度高于对照组(P<0.05)。治疗前,2组血浆胃动力素和生长抑素指标比较差异无统计学意义(P>0.05),治疗后,血浆胃动力素水平上升,生长抑素水平下降,刺激组改善程度高于对照组(P<0.05)。进餐后刺激组的胃排空率均高于对照组,进餐30、60 min后,刺激组胃排空率高于对照组(P<0.05)。治疗后,随访6个月,刺激组SF-36评分均高于对照组,除精神健康外差异均有统计学意义(P<0.05)。结论功能消化不良患儿行经皮电刺激治疗后,可以改善临床症状、胃排空率,提高生活质量,这可能和降低生长抑素,提高血浆胃动力素有关。更多还原

【Abstract】 Objective To explore the effect of transcutaneous electrical nerve stimulation on gastrointestinal symptoms in children with functional dyspepsia and abdominal pain syndrome. Methods Ninety-four children with functional dyspepsia and epigastric pain syndrome from June 2015 to June 2017 were selected and randomly divided into the experiment group and the control group, 47 cases in each group. The experiment group was treated with TENS, and the control group was routinely treated. Results Before treatment, two groups of children had no statistical significance in each symptom index(P>0.05). After treatment, the symptoms of the two groups were improved to a certain extent, and the degree of symptom recovery in the experiment group was signi?cantly higher than that in the control group(P<0.05). There was no signi?cant difference in plasma gastrin and somatostatin before treatment(P>0.05). However after treatment, plasma gastrin level increased, somatostatin level decreased, and the improvement in the conditions of patients in experiment group was significantly higher than that in control group(P<0.05). After meal, the gastric emptying rate of the experiment group was higher than that of the control group. After 30 min to 60 min, the gastric emptying rate in the experiment group was signi?cantly higher than that of the control group(P<0.05). After treatment and 6 months follow-up, the SF-36 score of stimulation group was higher than that of control group, with significant difference except mental health(P<0.05). Conclusion Functional dyspepsia can improve their clinical symptoms, gastric emptying rate and life quality after transcutaneous electrical stimulation, which may be related to the decreased levels of somatostatin and plasma gastrin.更多还原