【摘要】 目的探讨川芎嗪注射液联合硫酸沙丁胺醇治疗小儿支气管哮喘（bronchial asthma,BA）的效果分析及对血清25-羟维生素D₃[25-（OH）D₃]、肿瘤坏死因子-α（TNF-α）和免疫球蛋白E（IgE）的影响。方法选取2016年6月—2017年11月吉林大学校医院收治的128例小儿支气管哮喘患者。根据随机区组设计法将患者分为观察组和对照组（n=64）。对照组采用硫酸沙丁胺醇治疗,观察组采用川芎嗪注射液联合硫酸沙丁胺醇治疗。比较2组患者临床疗效、肺功能指标、临床症状、血清生化指标[25-（OH）D₃、TNF-α、IgE]、ACT评分及不良反应发生情况。结果观察组的总有效率（95.3%）显著高于对照组（73.4%）（P<0.05）。观察组患者FEV1、FVC、PEF均高于对照组（P<0.05）。观察组患者哮喘发作次数、哮喘持续时间、呼吸道感染次数改善情况均优于对照组（P<0.05）。观察组血清25-（OH）D₃高于对照组,TNF-α和IgE低于对照组（P<0.05）。观察组ACT评分显著高于对照组（P<0.05）。2组患者均未发生明显不良反应。结论川芎嗪注射液联合硫酸沙丁胺醇可显著改善BA患儿的肺功能,抑制细胞因子的表达,提高生活质量。更多还原

【Abstract】 Objective To investigate the therapeutic effect of ligustrazine injection combined with salbutamol sulfate against bronchial asthma and its effect on serum 25-（OH）D₃, TNF-a and IgE. Methods One hundred and twenty-eight cases of bronchial asthma treated in the Medical Department of Jilin University between June 2016 and November 2017 were selected and divided into the observation group and control group（n=64） using the random area group design method.The control group was treated with salbutamol sulfate, and the observation group with ligustrazine injection combined with salbutamol sulfate. The clinical effect, pulmonary function index, clinical symptoms, serum biochemical indexes[25-（OH）D₃,TNF-α, IgE], ACT score and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group（95.3%） was significantly higher than that of the control group（73.4%）（P<0.05）.FEV1, FVC and PEF in the observation group were significantly higher than those in the control group（P<0.05）. The frequency of asthma attacks, duration of asthma and incidence of respiratory infections were improved more significantly in the observation group than in the control group（P<0.05）. The level of serum 25-（OH） D₃ of the observation group was significantly higher than that of the control group, while the levels of TNF-a and IgE were significantly lower（P<0.05）.The score of ACT in the observation group was significantly higher than that of the control group（P<0.05）. No significant adverse reactions were found in either group. Conclusion Ligustrazine injection combined with salbutamol sulfate can significantly improve the lung function and clinical symptoms, inhibit the expression of cytokines and improve the life quality of patients with bronchial asthma.更多还原