【摘要】 目的探讨膀胱副神经节瘤(PUB)的临床病理特征及诊断治疗方法。方法回顾性分析2007年11月至2018年7月我院收治的6例膀胱副神经节瘤患者临床资料,总结分析膀胱副神经节瘤的临床病理特点和诊治要点。结果 6例患者中男性1例,女性5例,平均年龄42(23～55)岁,所有患者均为无功能性肿瘤,1例临床表现为尿痛,5例为体检发现膀胱占位。CT增强扫描明显强化。肿瘤均为单发,平均直径1.6(0.8～2.2)cm。1例行腹腔镜膀胱部分切除术,1例行膀胱部分切除术,4例行经尿道膀胱肿瘤电切术。平均手术时间72(35～130)min,平均估计出血量22(10～50) ml。术后病理6例均有阳性表达神经内分泌标志物Cg A、CD56和Syn,而上皮性标志物如CK、CEA等为阴性。术后随访8个月至11年,1例于经尿道膀胱肿瘤电切术(TURBT)术后5年复发,其余5例均无肿瘤复发或转移。结论膀胱副神经节瘤临床罕见,可无明显症状,CT增强扫描结合免疫组化检测可明确诊断,经尿道膀胱肿瘤电切术安全、有效,术后需长期随访。更多还原

【Abstract】 Objective To investigate the clinicopathological features, diagnosis and treatment of paraganglioma of urinary bladder(PUB). Methods The clinicopathological and follow-up data of 6 patients with paraganglioma of urinary bladder treated during November 2008 and July 2018 in our hospital were retrospectively analyzed. Results The six cases involved 1 males and 5 females with the average age of 42(23-55) years. All cases were nonfunctional neoplasm. All the lesions were solitary with an average diameter of 1.6(0.8-2.2) cm. One case had the symptom of urodynia, the other 5 cases were asymptomatic. CT scan was significantly enhanced. One case underwent laparoscopic partial cystectomy, one case underwent partial cystectomy, and the other 4 cases underwent transurethral resection of bladder tumor(TURBT). The average duration of operation was 72(35-130) min. The average estimated blood loss was 22(10-50) ml. Immunohistochemistry showed neuroendocrine markers(e.g. CgA, CD56 and Syn) were expressed in all cases, while epithelial markers(e.g. CK, CEA) were negative. During the follow-up of 8 months to 11 years, one patient suffered from recurrent tumor 5 years after initial TURBT. The other five cases had no recurrence or metastasis. Conclusions PUB is a rare tumor which has no obvious symptoms. A definite diagnosis can be made by CT scan combined with immunohistochemistry. TURBT was safe and effective. The life-long follow-up of these lesions was indispensable.更多还原