【摘要】 目的:了解老年口咽鳞癌患者的临床病理学特点,分析其采用初期手术进行治疗的预后相关因素。方法:收集2008至2013年于北京大学口腔医院行初期手术治疗的老年原发口咽鳞状细胞癌患者的年龄、性别、肿瘤部位、首发症状、吸烟史、饮酒史、临床分期、手术治疗、淋巴结转移情况、肿瘤分化程度、放化疗情况及肿瘤复发转移、生存情况,进行统计分析。结果:共45例患者符合纳入标准,平均年龄66岁,男性患者占大多数(32/45),吸烟(62. 2%)、饮酒(46. 7%)问题仍然严重。颈部淋巴转移率60%,Ⅱ区转移最常见。3年疾病特异性生存率、总生存率、无复发转移生存率分别为70. 8%、68. 3%、66. 1%。在多因素分析中,淋巴结分期、术后辅助放疗成为预后因素。结论:老年口咽鳞癌患者吸烟饮酒问题严重,临床肿瘤分期常为晚期,采用初期手术治疗效果良好,淋巴结转移及术后辅助放疗与否可能影响患者预后。更多还原

【Abstract】 Objective: To investigate the clinicopathological features of elderly patients with oropharynx carcinoma and to analyze the prognostic factors of early operation. Methods: In this study, we retrospectively collected and analyzed the data(age, gender, tumor location, symptom, smoking and drinking history, clinical stage, surgical treatments, lymph nodes metastasis, tumor differentiation, radical and chemical therapy, recurrence and metastasis, survival) of the patients who were no less than 60 years old and diagnosed with primary OPSCC and treated with conventional surgery as first-line therapy in this hospital from January 2008 to December 2013 in an attempt to evaluate the outcomes of squamous cell carcinoma of the oropharynx treated with primary surgery and identify the associated prognostic factors. Results: A total of 45 patients met the inclusion criteria, with an average age of 66 years old. Most of the patients were male(32/45), and smoking(62.2%)and drinking(46.7%) remained serious problems Neck metastasis rate was 60% and level Ⅱ nodes were the most vulnerable.The 3-year disease-specific survival, overall survival, and disease-free survival rates were 70.8%, 68.3%, 66.1%, respectively.A multivariate analysis indicated that N stage and adjuvant radiotherapy were predictive factors for 3-year disease-specific survival. Conclusion: Elderly patients with oropharyngeal squamous cell carcinoma have a serious problem of smoking and drinking alcohol, and the clinical tumor stage is often in the late stage. The early surgical treatment has a good effect, and the prognosis of patients may be affected by lymph node metastasis and postoperative adjuvant radiotherapy.更多还原