【摘要】 胃癌是严重危害人类健康的恶性肿瘤,其化疗耐药问题日趋严重,导致胃癌治疗有效率下降。胃癌局部微环境的缺氧是导致胃癌化疗耐药的一个重要原因,由于肿瘤内血管结构和功能的异常以及肿瘤细胞的快速增殖引起肿瘤细胞氧耗增加,导致肿瘤组织局部缺氧,结果肿瘤细胞更具有侵袭性,容易发生远处转移,并且对化疗产生抵抗。本文从导致胃癌组织内缺氧的原因及缺氧微环境的特征、缺氧引起胃癌化疗耐药的现状及原因、改善缺氧导致的胃癌化疗耐药的措施等几个方面就缺氧导致胃癌化疗耐药的研究进展进行综述。更多还原

【Abstract】 Gastric cancer is a serious malignancy that endangers human health. Increased rates of chemotherapy-resistant cancer have led to a decrease in the efficacy of treatment. Recent studies found that the presence of hypoxia in the tumor microenvironment was a notable cause of gastric cancer resistance to chemotherapy drugs. The abnormal structure and function of blood vessels in the tumor and the rapid proliferation of tumor cells increase the oxygen consumption of tumor cells, which results in tumor tissue hypoxia. Hypoxic conditions make tumor cells more aggressive, more likely to metastasize and develop resistance to chemotherapy. In this paper, we have reviewed the progress of research into hypoxia-induced chemotherapeutic drug resistance in gastric cancer. The review has covered the causes of hypoxia and the characteristics of the hypoxic microenvironment in gastric cancer, the current situation and causes of hypoxia-induced chemotherapeutic drug resistance in gastric cancer, and the measures to overcome the hypoxia-induced resistance to chemotherapy drugs.更多还原