【摘要】 静电纺丝技术为载药系统的构建开辟了新方法。载药电纺丝纳米纤维具有与细胞外基质形态结构相近、通气性好和吸湿性强等独特的纤维形貌,尤其适于经皮给药系统的应用。笔者通过归纳分析电纺载药纳米纤维的含义与特点、基质材料选择、制备方法、载药形式与释药特征,及其在经皮递药系统的应用,为电纺纳米纤维经皮给药系统相关研究提供借鉴。更多还原

【Abstract】 Electrospinning technology opens up a new method for the construction of drug delivery system. The unique fiber structures of drug-loaded electrospinning nanofibers with the characteristics of similar to the extracellular matrix,good air permeability and hygroscopicity are very suitable for transdermal drug delivery systems. In this paper,the definition,characteristics,matrix selection,preparation methods,drug-loaded forms and drug-released profiles of drug-loaded electrospinning nanofibers are summarized and analyzed. Meanwhile,the application of drug-loaded electrospinning nanofbiers in the transdermal drug delivery systems is analyzed. This review is to provide support for the further studies on electrospun nanofiber transdermal drug delivery system.更多还原